Effect of acidic fibroblast growth factor (FGF-1) delivered through a porous fibrin scaffold on meshed skin grafts

Scott W. Osborne; Barbara Blum; Dale Feldman; Stacey Kelpke; Abhay Pandit; J. Anthony Thompson

Effect of acidic fibroblast growth factor (FGF-1) delivered through a porous fibrin scaffold on meshed skin grafts

Scott W. Osborne, Barbara Blum, Dale Feldman, Stacey Kelpke, Abhay Pandit, J. Anthony Thompson

University of Alabama at Birmingham

Research output: Contribution to conference (Published) › Paper › peer-review

Abstract

Efforts are underway to develop a technique which will accelerate the acceptance of skin grafts and hasten the establishment of functional circulation in the treatment of burns. A proposed method involves the use of acidic fibroblast growth factor (FGF-1) which is delivered through a porous fibrin matrix on the angiogenic, epithelial, and fibroblastic response of the skin graft. In vivo testing was conducted using a partial thickness defect model in 12 New Zealand rabbits with two time periods. A relatively constant rate of FGF-1 release was observed. The FGF-1 exhibited greater angiogenesis, increased cellular infiltration, and overall healing rate over the non-FGF-1 adhesives.

Original language	English
Pages	27
Number of pages	1
Publication status	Published - 1996
Externally published	Yes
Event	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: 29 May 1996 → 2 Jun 1996

Conference

Conference	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
City	Toronto, Can
Period	29/05/96 → 2/06/96

Cite this

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title = "Effect of acidic fibroblast growth factor (FGF-1) delivered through a porous fibrin scaffold on meshed skin grafts",

abstract = "Efforts are underway to develop a technique which will accelerate the acceptance of skin grafts and hasten the establishment of functional circulation in the treatment of burns. A proposed method involves the use of acidic fibroblast growth factor (FGF-1) which is delivered through a porous fibrin matrix on the angiogenic, epithelial, and fibroblastic response of the skin graft. In vivo testing was conducted using a partial thickness defect model in 12 New Zealand rabbits with two time periods. A relatively constant rate of FGF-1 release was observed. The FGF-1 exhibited greater angiogenesis, increased cellular infiltration, and overall healing rate over the non-FGF-1 adhesives.",

author = "Osborne, \{Scott W.\} and Barbara Blum and Dale Feldman and Stacey Kelpke and Abhay Pandit and Thompson, \{J. Anthony\}",

year = "1996",

language = "English",

pages = "27",

note = "Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) ; Conference date: 29-05-1996 Through 02-06-1996",

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T1 - Effect of acidic fibroblast growth factor (FGF-1) delivered through a porous fibrin scaffold on meshed skin grafts

AU - Osborne, Scott W.

AU - Blum, Barbara

AU - Feldman, Dale

AU - Kelpke, Stacey

AU - Pandit, Abhay

AU - Thompson, J. Anthony

PY - 1996

Y1 - 1996

N2 - Efforts are underway to develop a technique which will accelerate the acceptance of skin grafts and hasten the establishment of functional circulation in the treatment of burns. A proposed method involves the use of acidic fibroblast growth factor (FGF-1) which is delivered through a porous fibrin matrix on the angiogenic, epithelial, and fibroblastic response of the skin graft. In vivo testing was conducted using a partial thickness defect model in 12 New Zealand rabbits with two time periods. A relatively constant rate of FGF-1 release was observed. The FGF-1 exhibited greater angiogenesis, increased cellular infiltration, and overall healing rate over the non-FGF-1 adhesives.

AB - Efforts are underway to develop a technique which will accelerate the acceptance of skin grafts and hasten the establishment of functional circulation in the treatment of burns. A proposed method involves the use of acidic fibroblast growth factor (FGF-1) which is delivered through a porous fibrin matrix on the angiogenic, epithelial, and fibroblastic response of the skin graft. In vivo testing was conducted using a partial thickness defect model in 12 New Zealand rabbits with two time periods. A relatively constant rate of FGF-1 release was observed. The FGF-1 exhibited greater angiogenesis, increased cellular infiltration, and overall healing rate over the non-FGF-1 adhesives.

UR - http://www.scopus.com/inward/record.url?scp=0030381470&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:0030381470

SP - 27

T2 - Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)

Y2 - 29 May 1996 through 2 June 1996

ER -

Effect of acidic fibroblast growth factor (FGF-1) delivered through a porous fibrin scaffold on meshed skin grafts

Abstract

Conference

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