TY - JOUR
T1 - Effect of acadesine on myocardial ischaemia in patients with coronary artery disease
AU - De Jonge, Robert
AU - MacLeod, Donald C.
AU - Suryapranata, Haryanto
AU - Van Es, Gerrit A.
AU - Friedman, John
AU - Serruys, Patrick W.
AU - De Jong, Jan W.
PY - 1997/10/15
Y1 - 1997/10/15
N2 - Acadesine, an adenosine regulating agent, attenuates the adverse effects of ischaemia on ventricular function in animals. This study examined its influence on pacing-induced ischaemia in 47 patients undergoing coronary angiography. After 15 min of recovery from control pacing, an infusion of acadesine (5, 10, 20, 50 mg/kg i.v.) was commenced and after a further 15 min the protocol was repeated with the infusion continued. At higher doses, minor beneficial effects on ejection fraction and myocardial lactate metabolism were observed, Haemodynamics were unaffected. Systemic lactate rose in relation to acadesine, up to 60% (P < 0.001 versus placebo). The data may indicate that acadesine stimulates anaerobic glycolysis in man.
AB - Acadesine, an adenosine regulating agent, attenuates the adverse effects of ischaemia on ventricular function in animals. This study examined its influence on pacing-induced ischaemia in 47 patients undergoing coronary angiography. After 15 min of recovery from control pacing, an infusion of acadesine (5, 10, 20, 50 mg/kg i.v.) was commenced and after a further 15 min the protocol was repeated with the infusion continued. At higher doses, minor beneficial effects on ejection fraction and myocardial lactate metabolism were observed, Haemodynamics were unaffected. Systemic lactate rose in relation to acadesine, up to 60% (P < 0.001 versus placebo). The data may indicate that acadesine stimulates anaerobic glycolysis in man.
KW - Adenosine
KW - Coronary artery disease
KW - Lactate
KW - Myocardial ischemia
KW - Ventricular function
UR - http://www.scopus.com/inward/record.url?scp=0030829976&partnerID=8YFLogxK
U2 - 10.1016/S0014-2999(97)01239-9
DO - 10.1016/S0014-2999(97)01239-9
M3 - Article
C2 - 9389379
AN - SCOPUS:0030829976
SN - 0014-2999
VL - 337
SP - 41
EP - 44
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -
