Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility.: Main and Epistatic Gene Effects Are Potential Contributors to Schizophrenia Susceptibility

GARY DONOHOE

doi:10.1016/j.biopsych.2006.12.025

Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility. Main and Epistatic Gene Effects Are Potential Contributors to Schizophrenia Susceptibility

GARY DONOHOE

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

54 Citations (Scopus)

Abstract

The DTNBP1 gene, encoding dysbindin, has been strongly implicated in schizophrenia (SZ) susceptibility by a series of independent genetic association and gene expression studies. Among its known functions, dysbindin is part of a protein complex, termed the biogenesis of lysosome-related organelles complex 1 (BLOC-1), the molecular components of which might be involved in the regulation of vesicular trafficking and dendrite branching.

Original language	English (Ireland)
Pages (from-to)	24-31
Number of pages	8
Journal	Biological Psychiatry
Volume	63
Issue number	1
DOIs	https://doi.org/10.1016/j.biopsych.2006.12.025
Publication status	Published - 1 Jan 2008

Keywords

BLOC-1
dysbindin
epistasis
gene
muted
schizophrenia

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Morris DW, Murphy K, Kenny N, Purcell SM, McGhee KA, Schwaiger S, Nangle JM, Donohoe G, Clarke S, Scully P, Quinn J, Meagher D, Baldwin P, Crumlish N, O'Callaghan E, Waddington JL, Gill M, Corvin AP

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DONOHOE, GARY. (2008). Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility. Main and Epistatic Gene Effects Are Potential Contributors to Schizophrenia Susceptibility. Biological Psychiatry, 63(1), 24-31. https://doi.org/10.1016/j.biopsych.2006.12.025

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DONOHOE, GARY 2008, 'Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility. Main and Epistatic Gene Effects Are Potential Contributors to Schizophrenia Susceptibility', Biological Psychiatry, vol. 63, no. 1, pp. 24-31. https://doi.org/10.1016/j.biopsych.2006.12.025

Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility. Main and Epistatic Gene Effects Are Potential Contributors to Schizophrenia Susceptibility. / DONOHOE, GARY.
In: Biological Psychiatry, Vol. 63, No. 1, 01.01.2008, p. 24-31.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

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