Dynamic combinatorial chemistry with novel dithiol building blocks: Towards new structurally diverse and adaptive screening collections

Tobias M. Postma; Warren R.J.D. Galloway; Fabien B.L. Cougnon; G. Dan Pantoş; Jamie E. Stokes; David R. Spring

doi:10.1055/s-0032-1318407

Dynamic combinatorial chemistry with novel dithiol building blocks: Towards new structurally diverse and adaptive screening collections

Tobias M. Postma, Warren R.J.D. Galloway, Fabien B.L. Cougnon, G. Dan Pantoş, Jamie E. Stokes, David R. Spring

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

10 Citations (Scopus)

Abstract

We describe the synthesis of a range of novel dithiol-functionalized building blocks and demonstrate how they can be used to generate new structurally diverse dynamic combinatorial libraries. A proof-of-principle experiment using the catecholamine dopamine revealed that molecular recognition changed the library composition under biocompatible conditions and identified new promising candidate receptors of this biologically important neurotransmitter.

Original language	English
Article number	ST-2013-D0042-L
Pages (from-to)	765-769
Number of pages	5
Journal	Synlett
Volume	24
Issue number	6
DOIs	https://doi.org/10.1055/s-0032-1318407
Publication status	Published - 2013
Externally published	Yes

Keywords

drugs
dynamic combinatorial chemistry
macrocycles
receptors
thiols

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10.1055/s-0032-1318407

Cite this

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abstract = "We describe the synthesis of a range of novel dithiol-functionalized building blocks and demonstrate how they can be used to generate new structurally diverse dynamic combinatorial libraries. A proof-of-principle experiment using the catecholamine dopamine revealed that molecular recognition changed the library composition under biocompatible conditions and identified new promising candidate receptors of this biologically important neurotransmitter.",

keywords = "drugs, dynamic combinatorial chemistry, macrocycles, receptors, thiols",

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AU - Pantoş, G. Dan

AU - Stokes, Jamie E.

AU - Spring, David R.

PY - 2013

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AB - We describe the synthesis of a range of novel dithiol-functionalized building blocks and demonstrate how they can be used to generate new structurally diverse dynamic combinatorial libraries. A proof-of-principle experiment using the catecholamine dopamine revealed that molecular recognition changed the library composition under biocompatible conditions and identified new promising candidate receptors of this biologically important neurotransmitter.

KW - drugs

KW - dynamic combinatorial chemistry

KW - macrocycles

KW - receptors

KW - thiols

UR - https://www.scopus.com/pages/publications/84874397866

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DO - 10.1055/s-0032-1318407

M3 - Article

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ER -

Dynamic combinatorial chemistry with novel dithiol building blocks: Towards new structurally diverse and adaptive screening collections

Abstract

Keywords

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