Duchenne and becker muscular dystrophy mutations: Analysis using 2.6 kb of muscle cDNA from the 5′ end of the gene

Terry J. Smith; Susan M. Forrest; Gareth S. Cross; Kay E. Davies

doi:10.1093/nar/15.23.9761

Duchenne and becker muscular dystrophy mutations: Analysis using 2.6 kb of muscle cDNA from the 5′ end of the gene

Terry J. Smith
, Susan M. Forrest
, Gareth S. Cross
, Kay E. Davies

John Radcliffe Hospital

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

17 Citations (Scopus)

Abstract

We have isolated overlapping human fetal muscle cDNAs encompassing 2.6kb which are localised very close to the 5′end of the Duchenne muscular dystrophy (DMD) gene. Using DNA from patients with deletions of previously reported genomic probes, we have mapped the exons across the region. Investigation of deletions in both DMD and Becker muscular dystrophy (BMD) patients shows the deletions to be present in 10% of cases and heterogeneous.

Original language	English
Pages (from-to)	9761-9769
Number of pages	9
Journal	Nucleic Acids Research
Volume	15
Issue number	23
DOIs	https://doi.org/10.1093/nar/15.23.9761
Publication status	Published - 10 Dec 1987
Externally published	Yes

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abstract = "We have isolated overlapping human fetal muscle cDNAs encompassing 2.6kb which are localised very close to the 5′end of the Duchenne muscular dystrophy (DMD) gene. Using DNA from patients with deletions of previously reported genomic probes, we have mapped the exons across the region. Investigation of deletions in both DMD and Becker muscular dystrophy (BMD) patients shows the deletions to be present in 10\% of cases and heterogeneous.",

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AU - Cross, Gareth S.

AU - Davies, Kay E.

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AB - We have isolated overlapping human fetal muscle cDNAs encompassing 2.6kb which are localised very close to the 5′end of the Duchenne muscular dystrophy (DMD) gene. Using DNA from patients with deletions of previously reported genomic probes, we have mapped the exons across the region. Investigation of deletions in both DMD and Becker muscular dystrophy (BMD) patients shows the deletions to be present in 10% of cases and heterogeneous.

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Duchenne and becker muscular dystrophy mutations: Analysis using 2.6 kb of muscle cDNA from the 5′ end of the gene

Abstract

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