Dual plasmonic gold nanostars for photoacoustic imaging and photothermal therapy

Róisín Dwyer; Ivan James Keogh; Peter Dockery; Haroon Zafar; Antony Wheatley; Martin Leahy; Cathal Ó Flatharta

doi:10.2217/nnm-2016-0318

Dual plasmonic gold nanostars for photoacoustic imaging and photothermal therapy

University of Galway
Royal College of Surgeons in Ireland
National Biophotonics and Imaging Platform
Singapore Bioimaging Consortium, Agency for Science Technology and Research

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

46 Citations (Scopus)

Abstract

Aim: To fabricate multimodal nanoconstruct that act as a single node for photoacoustic imaging (PAI) and photothermal therapy (PTT) in the fight against cancer. Materials methods: Dual plasmonic gold nanostars (DPGNS) were chemically synthesized by reducing gold precursor using ascorbic acid and silver ions as shape directing agent. PAI and PTT were performed using commonly available 1064 nm laser source on DPGNS embedded tumor xenografts on mice. Results conclusion: Photoacoustic amplitude increase with longer wavelength source and with silica coating of DPGNS. The in vivo photothermal capability of DPGNS resulted in a significant decrease in the tumor cellular area. DPGNS exhibited potential for single node diagnosis and therapy with longer wavelength facilitating deeper imaging and therapy.

Original language	English (Ireland)
Pages (from-to)	457-471
Number of pages	15
Journal	Nanomedicine
Volume	12
Issue number	5
DOIs	https://doi.org/10.2217/nnm-2016-0318
Publication status	Published - 1 Mar 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

gold nanostar
near infrared imaging
optical window
photoacoustic imaging
photothermal therapy
plasmonic nanoparticles
silica shell
surface plasmon resonance

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Raghavan, V,O'Flatharta, C,Dwyer, R,Breathnach, A,Zafar, H,Dockery, P,Wheatley, A,Keogh, I,Leahy, M,Olivo, M
Raghavan, V;O'Flatharta, C;Dwyer, R;Breathnach, A;Zafar, H;Dockery, P;Wheatley, A;Keogh, I;Leahy, M;Olivo, M
Raghavan, V. and O'Flatharta, C. and Dwyer, R. and Breathnach, A. and Zafar, H. and Dockery, P. and Wheatley, A. and Keogh, I. and Leahy, M. and Olivo, M.

Access to Document

10.2217/nnm-2016-0318

Cite this

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title = "Dual plasmonic gold nanostars for photoacoustic imaging and photothermal therapy",

abstract = "Aim: To fabricate multimodal nanoconstruct that act as a single node for photoacoustic imaging (PAI) and photothermal therapy (PTT) in the fight against cancer. Materials methods: Dual plasmonic gold nanostars (DPGNS) were chemically synthesized by reducing gold precursor using ascorbic acid and silver ions as shape directing agent. PAI and PTT were performed using commonly available 1064 nm laser source on DPGNS embedded tumor xenografts on mice. Results conclusion: Photoacoustic amplitude increase with longer wavelength source and with silica coating of DPGNS. The in vivo photothermal capability of DPGNS resulted in a significant decrease in the tumor cellular area. DPGNS exhibited potential for single node diagnosis and therapy with longer wavelength facilitating deeper imaging and therapy.",

keywords = "gold nanostar, near infrared imaging, optical window, photoacoustic imaging, photothermal therapy, plasmonic nanoparticles, silica shell, surface plasmon resonance",

author = "R{\'o}is{\'i}n Dwyer and Keogh, \{Ivan James\} and Peter Dockery and Haroon Zafar and Antony Wheatley and Martin Leahy and \{{\'O} Flatharta\}, Cathal",

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doi = "10.2217/nnm-2016-0318",

language = "English (Ireland)",

volume = "12",

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T1 - Dual plasmonic gold nanostars for photoacoustic imaging and photothermal therapy

AU - Dwyer, Róisín

AU - Keogh, Ivan James

AU - Dockery, Peter

AU - Zafar, Haroon

AU - Wheatley, Antony

AU - Leahy, Martin

AU - Ó Flatharta, Cathal

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Aim: To fabricate multimodal nanoconstruct that act as a single node for photoacoustic imaging (PAI) and photothermal therapy (PTT) in the fight against cancer. Materials methods: Dual plasmonic gold nanostars (DPGNS) were chemically synthesized by reducing gold precursor using ascorbic acid and silver ions as shape directing agent. PAI and PTT were performed using commonly available 1064 nm laser source on DPGNS embedded tumor xenografts on mice. Results conclusion: Photoacoustic amplitude increase with longer wavelength source and with silica coating of DPGNS. The in vivo photothermal capability of DPGNS resulted in a significant decrease in the tumor cellular area. DPGNS exhibited potential for single node diagnosis and therapy with longer wavelength facilitating deeper imaging and therapy.

AB - Aim: To fabricate multimodal nanoconstruct that act as a single node for photoacoustic imaging (PAI) and photothermal therapy (PTT) in the fight against cancer. Materials methods: Dual plasmonic gold nanostars (DPGNS) were chemically synthesized by reducing gold precursor using ascorbic acid and silver ions as shape directing agent. PAI and PTT were performed using commonly available 1064 nm laser source on DPGNS embedded tumor xenografts on mice. Results conclusion: Photoacoustic amplitude increase with longer wavelength source and with silica coating of DPGNS. The in vivo photothermal capability of DPGNS resulted in a significant decrease in the tumor cellular area. DPGNS exhibited potential for single node diagnosis and therapy with longer wavelength facilitating deeper imaging and therapy.

KW - gold nanostar

KW - near infrared imaging

KW - optical window

KW - photoacoustic imaging

KW - photothermal therapy

KW - plasmonic nanoparticles

KW - silica shell

KW - surface plasmon resonance

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Dual plasmonic gold nanostars for photoacoustic imaging and photothermal therapy

Abstract

UN SDGs

Keywords

Authors (Note for portal: view the doc link for the full list of authors)

Access to Document

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