Double-edged sword: A p53 regulator mediates both harmful and beneficial effects in experimental acute kidney injury

Bairbre A. McNicholas; Matthew D. Griffin

doi:10.1038/ki.2012.36

Double-edged sword: A p53 regulator mediates both harmful and beneficial effects in experimental acute kidney injury

Bairbre A. McNicholas, Matthew D. Griffin

Medicine

University of Galway

Research output: Contribution to a Journal (Peer & Non Peer) › Comment/debate

5 Citations (Scopus)

Abstract

Acute kidney injury triggers activation of innate immune responses and of proapoptotic programs such as the p53 pathway. Mulay et al. examine the effects of blocking murine double minute-2 (mdm2), a negative regulator of p53, using a novel chemotherapeutic agent, nutlin-3a, in mouse ischemia-reperfusion injury. Their results indicate that mdm2 promotes renal regeneration by limiting p53-mediated apoptosis but also enhances early inflammation by facilitating DNA binding of nuclear factor-B independently of p53.

Original language	English
Pages (from-to)	1161-1164
Number of pages	4
Journal	Kidney International
Volume	81
Issue number	12
DOIs	https://doi.org/10.1038/ki.2012.36
Publication status	Published - 2 Jun 2012

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10.1038/ki.2012.36

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abstract = "Acute kidney injury triggers activation of innate immune responses and of proapoptotic programs such as the p53 pathway. Mulay et al. examine the effects of blocking murine double minute-2 (mdm2), a negative regulator of p53, using a novel chemotherapeutic agent, nutlin-3a, in mouse ischemia-reperfusion injury. Their results indicate that mdm2 promotes renal regeneration by limiting p53-mediated apoptosis but also enhances early inflammation by facilitating DNA binding of nuclear factor-B independently of p53.",

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AB - Acute kidney injury triggers activation of innate immune responses and of proapoptotic programs such as the p53 pathway. Mulay et al. examine the effects of blocking murine double minute-2 (mdm2), a negative regulator of p53, using a novel chemotherapeutic agent, nutlin-3a, in mouse ischemia-reperfusion injury. Their results indicate that mdm2 promotes renal regeneration by limiting p53-mediated apoptosis but also enhances early inflammation by facilitating DNA binding of nuclear factor-B independently of p53.

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ER -

Double-edged sword: A p53 regulator mediates both harmful and beneficial effects in experimental acute kidney injury

Abstract

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