Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing

I.E. Jansen; H. Ye; S. Heetveld; M.C. Lechler; H. Michels; R.I. Seinstra; S.J. Lubbe; V. Drouet; S. Lesage; E. Majounie; J.R. Gibbs; M.A. Nalls; M. Ryten; J.A. Botia; J. Vandrovcova; J. Simon-Sanchez; M. Castillo-Lizardo; P. Rizzu; C. Blauwendraat; A.K. Chouhan; Y. Li; P. Yogi; N. Amin; C.M. van Duijn; H.R. Morris; A. Brice; A.B. Singleton; D.C. David; E.A. Nollen; S. Jain; J. Shulman; P. Heutink; D.G. Hernandez; S. Arepalli; J. Brooks; R. Price; A. Nicolas; S. Chong; M.R. Cookson; A. Dillman; M. Moore; B.J. Traynor; Andre Singleton; V. Plagnol; Nicholas W Wood; U.-M. Sheerin; Jose M Bras; G. Charlesworth; M. Gardner; R. Guerreiro; D. Trabzuni; J. Hardy; M. Sharma; M. Saad; Javier Simón-Sánchez; C. Schulte; J.C. Corvol; A. Dürr; M. Vidailhet; S. Sveinbjörnsdóttir; R. Barker; Y. Ben-Shlomo; H.W. Berendse; van Dijk; D. Berg; K. Brockmann; I. Wurster; W. Mätzler; T. Gasser; M. Martinez; R.M.A. de Bie; A. Biffi; D. Velseboer; B. Bloem; B. Post; M. Wickremaratchi; B. van de Warrenburg; Z. Bochdanovits; M. Bonin; H. Pétursson; O. Riess; D.J. Burn; S. Lubbe; J.M. Cooper; A. McNeill; A. Schapira; C. Lungu; H. Chen; J. Dong; P.F. Chinnery; G. Hudson; C.E. Clarke; C. Moorby; C. Counsell; P. Damier; J.-F. Dartigues; P. Deloukas; S. Edkins; S.E. Hunt; S. Potter; A. Tashakkori-Ghanbaria; G. Deuschl; D. Lorenz; D.T. Dexter; F. Durif; J.R. Evans; C. Langford; T. Foltynie; A. Goate; C. Harris; J.J. van Hilten; A. Hofman; A. Hollenbeck; J. Holton; M. Hu; X. Huang; T. Illig; P.V. Jónsson; J.-C. Lambert; S.S. O'Sullivan; T. Revesz; K. Shaw; A. Lees; P. Lichtner; P. Limousin; G. Lopez; V. Escott-Price; J. Pearson; N. Williams; E. Mudanohwo; J.S. Perlmutter; P. Pollak; F. Rivadeneira; A.G. Uitterlinden; S. Sawcer; H. Scheffer; I. Shoulson; J. Shulman; C. Smith; R. Walker; C.C.A. Spencer; A. Strange; H. Stefánsson; F. Bettella; K. Stefánsson; J.D. Stockton; K. Talbot; C.M. Tanner; F. Tison; S. Winder-Rhodes; K. Bhatia

doi:10.1186/s13059-017-1147-9

Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing

I.E. Jansen
, H. Ye
, S. Heetveld
, M.C. Lechler
, H. Michels
, R.I. Seinstra
, S.J. Lubbe
, V. Drouet
, S. Lesage
, E. Majounie
, J.R. Gibbs
, M.A. Nalls
, M. Ryten
, J.A. Botia
, J. Vandrovcova
, J. Simon-Sanchez
, M. Castillo-Lizardo
, P. Rizzu
, C. Blauwendraat
, A.K. Chouhan

Y. Li, P. Yogi, N. Amin, C.M. van Duijn, H.R. Morris, A. Brice, A.B. Singleton, D.C. David, E.A. Nollen, S. Jain, J. Shulman, P. Heutink, D.G. Hernandez, S. Arepalli, J. Brooks, R. Price, A. Nicolas, S. Chong, M.R. Cookson, A. Dillman, M. Moore, B.J. Traynor, Andre Singleton, V. Plagnol, Nicholas W Wood, U.-M. Sheerin, Jose M Bras, G. Charlesworth, M. Gardner, R. Guerreiro, D. Trabzuni, J. Hardy, M. Sharma, M. Saad, Javier Simón-Sánchez, C. Schulte, J.C. Corvol, A. Dürr, M. Vidailhet, S. Sveinbjörnsdóttir, R. Barker, Y. Ben-Shlomo, H.W. Berendse, van Dijk, D. Berg, K. Brockmann, I. Wurster, W. Mätzler, T. Gasser, M. Martinez, R.M.A. de Bie, A. Biffi, D. Velseboer, B. Bloem, B. Post, M. Wickremaratchi, B. van de Warrenburg, Z. Bochdanovits, M. Bonin, H. Pétursson, O. Riess, D.J. Burn, S. Lubbe, J.M. Cooper, A. McNeill, A. Schapira, C. Lungu, H. Chen, J. Dong, P.F. Chinnery, G. Hudson, C.E. Clarke, C. Moorby, C. Counsell, P. Damier, J.-F. Dartigues, P. Deloukas, S. Edkins, S.E. Hunt, S. Potter, A. Tashakkori-Ghanbaria, G. Deuschl, D. Lorenz, D.T. Dexter, F. Durif, J.R. Evans, C. Langford, T. Foltynie, A. Goate, C. Harris, J.J. van Hilten, A. Hofman, A. Hollenbeck, J. Holton, M. Hu, X. Huang, T. Illig, P.V. Jónsson, J.-C. Lambert, S.S. O'Sullivan, T. Revesz, K. Shaw, A. Lees, P. Lichtner, P. Limousin, G. Lopez, V. Escott-Price, J. Pearson, N. Williams, E. Mudanohwo, J.S. Perlmutter, P. Pollak, F. Rivadeneira, A.G. Uitterlinden, S. Sawcer, H. Scheffer, I. Shoulson, J. Shulman, C. Smith, R. Walker, C.C.A. Spencer, A. Strange, H. Stefánsson, F. Bettella, K. Stefánsson, J.D. Stockton, K. Talbot, C.M. Tanner, F. Tison, S. Winder-Rhodes, K. Bhatia

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

92 Citations (Scopus)

Original language	Undefined/Unknown
Journal	Genome Biology
DOIs	https://doi.org/10.1186/s13059-017-1147-9
Publication status	Published - 2017

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Jansen, I. E., Ye, H., Heetveld, S., Lechler, M. C., Michels, H., Seinstra, R. I., Lubbe, S. J., Drouet, V., Lesage, S., Majounie, E., Gibbs, J. R., Nalls, M. A., Ryten, M., Botia, J. A., Vandrovcova, J., Simon-Sanchez, J., Castillo-Lizardo, M., Rizzu, P., Blauwendraat, C., ... Bhatia, K. (2017). Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biology. https://doi.org/10.1186/s13059-017-1147-9

@article{97023c40e8404fee9f1ee0da1fb63df7,

title = "Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing",

author = "I.E. Jansen and H. Ye and S. Heetveld and M.C. Lechler and H. Michels and R.I. Seinstra and S.J. Lubbe and V. Drouet and S. Lesage and E. Majounie and J.R. Gibbs and M.A. Nalls and M. Ryten and J.A. Botia and J. Vandrovcova and J. Simon-Sanchez and M. Castillo-Lizardo and P. Rizzu and C. Blauwendraat and A.K. Chouhan and Y. Li and P. Yogi and N. Amin and \{van Duijn\}, C.M. and H.R. Morris and A. Brice and A.B. Singleton and D.C. David and E.A. Nollen and S. Jain and J. Shulman and P. Heutink and D.G. Hernandez and S. Arepalli and J. Brooks and R. Price and A. Nicolas and S. Chong and M.R. Cookson and A. Dillman and M. Moore and B.J. Traynor and Andre Singleton and V. Plagnol and Wood, \{Nicholas W\} and U.-M. Sheerin and Bras, \{Jose M\} and G. Charlesworth and M. Gardner and R. Guerreiro and D. Trabzuni and J. Hardy and M. Sharma and M. Saad and Javier Sim{\'o}n-S{\'a}nchez and C. Schulte and J.C. Corvol and A. D{\"u}rr and M. Vidailhet and S. Sveinbj{\"o}rnsd{\'o}ttir and R. Barker and Y. Ben-Shlomo and H.W. Berendse and \{van Dijk\} and D. Berg and K. Brockmann and I. Wurster and W. M{\"a}tzler and T. Gasser and M. Martinez and \{de Bie\}, R.M.A. and A. Biffi and D. Velseboer and B. Bloem and B. Post and M. Wickremaratchi and \{van de Warrenburg\}, B. and Z. Bochdanovits and M. Bonin and H. P{\'e}tursson and O. Riess and D.J. Burn and S. Lubbe and J.M. Cooper and A. McNeill and A. Schapira and C. Lungu and H. Chen and J. Dong and P.F. Chinnery and G. Hudson and C.E. Clarke and C. Moorby and C. Counsell and P. Damier and J.-F. Dartigues and P. Deloukas and S. Edkins and S.E. Hunt and S. Potter and A. Tashakkori-Ghanbaria and G. Deuschl and D. Lorenz and D.T. Dexter and F. Durif and J.R. Evans and C. Langford and T. Foltynie and A. Goate and C. Harris and \{van Hilten\}, J.J. and A. Hofman and A. Hollenbeck and J. Holton and M. Hu and X. Huang and T. Illig and P.V. J{\'o}nsson and J.-C. Lambert and S.S. O'Sullivan and T. Revesz and K. Shaw and A. Lees and P. Lichtner and P. Limousin and G. Lopez and V. Escott-Price and J. Pearson and N. Williams and E. Mudanohwo and J.S. Perlmutter and P. Pollak and F. Rivadeneira and A.G. Uitterlinden and S. Sawcer and H. Scheffer and I. Shoulson and J. Shulman and C. Smith and R. Walker and C.C.A. Spencer and A. Strange and H. Stef{\'a}nsson and F. Bettella and K. Stef{\'a}nsson and J.D. Stockton and K. Talbot and C.M. Tanner and F. Tison and S. Winder-Rhodes and K. Bhatia",

year = "2017",

doi = "10.1186/s13059-017-1147-9",

language = "Undefined/Unknown",

journal = "Genome Biology",

}

Jansen, IE, Ye, H, Heetveld, S, Lechler, MC, Michels, H, Seinstra, RI, Lubbe, SJ, Drouet, V, Lesage, S, Majounie, E, Gibbs, JR, Nalls, MA, Ryten, M, Botia, JA, Vandrovcova, J, Simon-Sanchez, J, Castillo-Lizardo, M, Rizzu, P, Blauwendraat, C, Chouhan, AK, Li, Y, Yogi, P, Amin, N, van Duijn, CM, Morris, HR, Brice, A, Singleton, AB, David, DC, Nollen, EA, Jain, S, Shulman, J, Heutink, P, Hernandez, DG, Arepalli, S, Brooks, J, Price, R, Nicolas, A, Chong, S, Cookson, MR, Dillman, A, Moore, M, Traynor, BJ, Singleton, A, Plagnol, V, Wood, NW, Sheerin, U-M, Bras, JM, Charlesworth, G, Gardner, M, Guerreiro, R, Trabzuni, D, Hardy, J, Sharma, M, Saad, M, Simón-Sánchez, J, Schulte, C, Corvol, JC, Dürr, A, Vidailhet, M, Sveinbjörnsdóttir, S, Barker, R, Ben-Shlomo, Y, Berendse, HW, van Dijk, Berg, D, Brockmann, K, Wurster, I, Mätzler, W, Gasser, T, Martinez, M, de Bie, RMA, Biffi, A, Velseboer, D, Bloem, B, Post, B, Wickremaratchi, M, van de Warrenburg, B, Bochdanovits, Z, Bonin, M, Pétursson, H, Riess, O, Burn, DJ, Lubbe, S, Cooper, JM, McNeill, A, Schapira, A, Lungu, C, Chen, H, Dong, J, Chinnery, PF, Hudson, G, Clarke, CE, Moorby, C, Counsell, C, Damier, P, Dartigues, J-F, Deloukas, P, Edkins, S, Hunt, SE, Potter, S, Tashakkori-Ghanbaria, A, Deuschl, G, Lorenz, D, Dexter, DT, Durif, F, Evans, JR, Langford, C, Foltynie, T, Goate, A, Harris, C, van Hilten, JJ, Hofman, A, Hollenbeck, A, Holton, J, Hu, M, Huang, X, Illig, T, Jónsson, PV, Lambert, J-C, O'Sullivan, SS, Revesz, T, Shaw, K, Lees, A, Lichtner, P, Limousin, P, Lopez, G, Escott-Price, V, Pearson, J, Williams, N, Mudanohwo, E, Perlmutter, JS, Pollak, P, Rivadeneira, F, Uitterlinden, AG, Sawcer, S, Scheffer, H, Shoulson, I, Shulman, J, Smith, C, Walker, R, Spencer, CCA, Strange, A, Stefánsson, H, Bettella, F, Stefánsson, K, Stockton, JD, Talbot, K, Tanner, CM, Tison, F, Winder-Rhodes, S & Bhatia, K 2017, 'Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing', Genome Biology. https://doi.org/10.1186/s13059-017-1147-9

TY - JOUR

T1 - Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing

AU - Jansen, I.E.

AU - Ye, H.

AU - Heetveld, S.

AU - Lechler, M.C.

AU - Michels, H.

AU - Seinstra, R.I.

AU - Lubbe, S.J.

AU - Drouet, V.

AU - Lesage, S.

AU - Majounie, E.

AU - Gibbs, J.R.

AU - Nalls, M.A.

AU - Ryten, M.

AU - Botia, J.A.

AU - Vandrovcova, J.

AU - Simon-Sanchez, J.

AU - Castillo-Lizardo, M.

AU - Rizzu, P.

AU - Blauwendraat, C.

AU - Chouhan, A.K.

AU - Li, Y.

AU - Yogi, P.

AU - Amin, N.

AU - van Duijn, C.M.

AU - Morris, H.R.

AU - Brice, A.

AU - Singleton, A.B.

AU - David, D.C.

AU - Nollen, E.A.

AU - Jain, S.

AU - Shulman, J.

AU - Heutink, P.

AU - Hernandez, D.G.

AU - Arepalli, S.

AU - Brooks, J.

AU - Price, R.

AU - Nicolas, A.

AU - Chong, S.

AU - Cookson, M.R.

AU - Dillman, A.

AU - Moore, M.

AU - Traynor, B.J.

AU - Singleton, Andre

AU - Plagnol, V.

AU - Wood, Nicholas W

AU - Sheerin, U.-M.

AU - Bras, Jose M

AU - Charlesworth, G.

AU - Gardner, M.

AU - Guerreiro, R.

AU - Trabzuni, D.

AU - Hardy, J.

AU - Sharma, M.

AU - Saad, M.

AU - Simón-Sánchez, Javier

AU - Schulte, C.

AU - Corvol, J.C.

AU - Dürr, A.

AU - Vidailhet, M.

AU - Sveinbjörnsdóttir, S.

AU - Barker, R.

AU - Ben-Shlomo, Y.

AU - Berendse, H.W.

AU - van Dijk,

AU - Berg, D.

AU - Brockmann, K.

AU - Wurster, I.

AU - Mätzler, W.

AU - Gasser, T.

AU - Martinez, M.

AU - de Bie, R.M.A.

AU - Biffi, A.

AU - Velseboer, D.

AU - Bloem, B.

AU - Post, B.

AU - Wickremaratchi, M.

AU - van de Warrenburg, B.

AU - Bochdanovits, Z.

AU - Bonin, M.

AU - Pétursson, H.

AU - Riess, O.

AU - Burn, D.J.

AU - Lubbe, S.

AU - Cooper, J.M.

AU - McNeill, A.

AU - Schapira, A.

AU - Lungu, C.

AU - Chen, H.

AU - Dong, J.

AU - Chinnery, P.F.

AU - Hudson, G.

AU - Clarke, C.E.

AU - Moorby, C.

AU - Counsell, C.

AU - Damier, P.

AU - Dartigues, J.-F.

AU - Deloukas, P.

AU - Edkins, S.

AU - Hunt, S.E.

AU - Potter, S.

AU - Tashakkori-Ghanbaria, A.

AU - Deuschl, G.

AU - Lorenz, D.

AU - Dexter, D.T.

AU - Durif, F.

AU - Evans, J.R.

AU - Langford, C.

AU - Foltynie, T.

AU - Goate, A.

AU - Harris, C.

AU - van Hilten, J.J.

AU - Hofman, A.

AU - Hollenbeck, A.

AU - Holton, J.

AU - Hu, M.

AU - Huang, X.

AU - Illig, T.

AU - Jónsson, P.V.

AU - Lambert, J.-C.

AU - O'Sullivan, S.S.

AU - Revesz, T.

AU - Shaw, K.

AU - Lees, A.

AU - Lichtner, P.

AU - Limousin, P.

AU - Lopez, G.

AU - Escott-Price, V.

AU - Pearson, J.

AU - Williams, N.

AU - Mudanohwo, E.

AU - Perlmutter, J.S.

AU - Pollak, P.

AU - Rivadeneira, F.

AU - Uitterlinden, A.G.

AU - Sawcer, S.

AU - Scheffer, H.

AU - Shoulson, I.

AU - Shulman, J.

AU - Smith, C.

AU - Walker, R.

AU - Spencer, C.C.A.

AU - Strange, A.

AU - Stefánsson, H.

AU - Bettella, F.

AU - Stefánsson, K.

AU - Stockton, J.D.

AU - Talbot, K.

AU - Tanner, C.M.

AU - Tison, F.

AU - Winder-Rhodes, S.

AU - Bhatia, K.

PY - 2017

Y1 - 2017

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-85011019247&partnerID=MN8TOARS

U2 - 10.1186/s13059-017-1147-9

DO - 10.1186/s13059-017-1147-9

M3 - Article

JO - Genome Biology

JF - Genome Biology

ER -

Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing

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