Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

Oxford University Hospitals Staff Testing Group

doi:10.7554/ELIFE.60675

Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

Oxford University Hospitals Staff Testing Group

Medicine

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

196 Citations (Scopus)

Abstract

We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034(11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45-6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99-3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07-2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28-0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25-2.21]) and Asian (1.51 [1.28-1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34-3.15]).

Original language	English
Article number	e60675
Pages (from-to)	1-37
Number of pages	37
Journal	eLife
Volume	9
DOIs	https://doi.org/10.7554/ELIFE.60675
Publication status	Published - Aug 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.7554/ELIFE.60675

Cite this

@article{05a7545a955643c4b6aac0f87fc49653,

title = "Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study",

abstract = "We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034(11.2\%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95\%CI 3.45-6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6\% vs. 8.6\% elsewhere) (aOR 2.47 [1.99-3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07-2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28-0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25-2.21]) and Asian (1.51 [1.28-1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34-3.15]).",

author = "\{Oxford University Hospitals Staff Testing Group\} and Eyre, \{David W.\} and Lumley, \{Sheila F.\} and Denise O{\textquoteright}donnell and Mark Campbell and Elizabeth Sims and Elaine Lawson and Fiona Warren and Tim James and Stuart Cox and Alison Howarth and George Doherty and Hatch, \{Stephanie B.\} and James Kavanagh and Chau, \{Kevin K.\} and Fowler, \{Philip W.\} and Jeremy Swann and Denis Volk and Fan Yang-Turner and Stoesser, \{Nicole E.\} and Matthews, \{Philippa C.\} and Maria Dudareva and Timothy Davies and Shaw, \{Robert H.\} and Leon Peto and Downs, \{Louise O.\} and Alexander Vogt and Ali Amini and Young, \{Bernadette C.\} and Philip Drennan and Mentzer, \{Alexander J.\} and Donal Skelly and Fredrik Karpe and Neville, \{Matt J.\} and Monique Andersson and Brent, \{Andrew J.\} and Nicola Jones and Ferreira, \{Lucas Martins\} and Thomas Christott and Marsden, \{Brian D.\} and Sarah Hoosdally and Richard Cornall and Crook, \{Derrick W.\} and Stuart, \{David I.\} and Gavin Screaton and Peto, \{Timothy E.A.\} and Bruno Holthof and O{\textquoteright}donnell, \{Anne Marie\} and Daniel Ebner and Conlon, \{Christopher P.\} and Katie Jeffery and Walker, \{Timothy M.\} and Watson, \{Adam J.R.\} and Adan Taylor and Alan Chetwynd and Alexander Grassam-Rowe and Mighiu, \{Alexandra S.\} and Angus Livingstone and Annabel Killen and Caitlin Rigler and Callum Harries and Cameron East and Charlotte Lee and Mason, \{Chris J.B.\} and Christian Holland and Connor Thompson and Conor Hennesey and Constantinos Savva and Kim, \{David S.\} and Harris, \{Edward W.A.\} and McGivern, \{Euan J.\} and Evelyn Qian and Evie Rothwell and Francesca Back and Gabriella Kelly and Gareth Watson and Gregory Howgego and Hannah Chase and Hannah Danbury and Hannah Laurenson-Schafer and Ward, \{Harry L.\} and Holly Hendron and Vorley, \{Imogen C.\} and Isabel Tol and James Gunnell and Ward, \{Jocelyn L.F.\} and Jonathan Drake and Wilson, \{Joseph D.\} and Joshua Morton and Julie Dequaire and Katherine O'Byrne and Kenzo Motohashi and Kirsty Harper and Krupa Ravi and Millar, \{Lancelot J.\} and Peck, \{Liam J.\} and Madeleine Oliver and English, \{Marcus Rex\} and Mary Kumarendran and Matthew Wedlich and Ritter, \{Thomas G.\}",

year = "2020",

month = aug,

doi = "10.7554/ELIFE.60675",

language = "English",

volume = "9",

pages = "1--37",

journal = "eLife",

issn = "2050-084X",

publisher = "eLife Sciences Publications Ltd",

}

TY - JOUR

T1 - Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

AU - Oxford University Hospitals Staff Testing Group

AU - Eyre, David W.

AU - Lumley, Sheila F.

AU - O’donnell, Denise

AU - Campbell, Mark

AU - Sims, Elizabeth

AU - Lawson, Elaine

AU - Warren, Fiona

AU - James, Tim

AU - Cox, Stuart

AU - Howarth, Alison

AU - Doherty, George

AU - Hatch, Stephanie B.

AU - Kavanagh, James

AU - Chau, Kevin K.

AU - Fowler, Philip W.

AU - Swann, Jeremy

AU - Volk, Denis

AU - Yang-Turner, Fan

AU - Stoesser, Nicole E.

AU - Matthews, Philippa C.

AU - Dudareva, Maria

AU - Davies, Timothy

AU - Shaw, Robert H.

AU - Peto, Leon

AU - Downs, Louise O.

AU - Vogt, Alexander

AU - Amini, Ali

AU - Young, Bernadette C.

AU - Drennan, Philip

AU - Mentzer, Alexander J.

AU - Skelly, Donal

AU - Karpe, Fredrik

AU - Neville, Matt J.

AU - Andersson, Monique

AU - Brent, Andrew J.

AU - Jones, Nicola

AU - Ferreira, Lucas Martins

AU - Christott, Thomas

AU - Marsden, Brian D.

AU - Hoosdally, Sarah

AU - Cornall, Richard

AU - Crook, Derrick W.

AU - Stuart, David I.

AU - Screaton, Gavin

AU - Peto, Timothy E.A.

AU - Holthof, Bruno

AU - O’donnell, Anne Marie

AU - Ebner, Daniel

AU - Conlon, Christopher P.

AU - Jeffery, Katie

AU - Walker, Timothy M.

AU - Watson, Adam J.R.

AU - Taylor, Adan

AU - Chetwynd, Alan

AU - Grassam-Rowe, Alexander

AU - Mighiu, Alexandra S.

AU - Livingstone, Angus

AU - Killen, Annabel

AU - Rigler, Caitlin

AU - Harries, Callum

AU - East, Cameron

AU - Lee, Charlotte

AU - Mason, Chris J.B.

AU - Holland, Christian

AU - Thompson, Connor

AU - Hennesey, Conor

AU - Savva, Constantinos

AU - Kim, David S.

AU - Harris, Edward W.A.

AU - McGivern, Euan J.

AU - Qian, Evelyn

AU - Rothwell, Evie

AU - Back, Francesca

AU - Kelly, Gabriella

AU - Watson, Gareth

AU - Howgego, Gregory

AU - Chase, Hannah

AU - Danbury, Hannah

AU - Laurenson-Schafer, Hannah

AU - Ward, Harry L.

AU - Hendron, Holly

AU - Vorley, Imogen C.

AU - Tol, Isabel

AU - Gunnell, James

AU - Ward, Jocelyn L.F.

AU - Drake, Jonathan

AU - Wilson, Joseph D.

AU - Morton, Joshua

AU - Dequaire, Julie

AU - O'Byrne, Katherine

AU - Motohashi, Kenzo

AU - Harper, Kirsty

AU - Ravi, Krupa

AU - Millar, Lancelot J.

AU - Peck, Liam J.

AU - Oliver, Madeleine

AU - English, Marcus Rex

AU - Kumarendran, Mary

AU - Wedlich, Matthew

AU - Ritter, Thomas G.

PY - 2020/8

Y1 - 2020/8

N2 - We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034(11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45-6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99-3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07-2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28-0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25-2.21]) and Asian (1.51 [1.28-1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34-3.15]).

AB - We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034(11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45-6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99-3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07-2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28-0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25-2.21]) and Asian (1.51 [1.28-1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34-3.15]).

UR - https://www.scopus.com/pages/publications/85090837873

U2 - 10.7554/ELIFE.60675

DO - 10.7554/ELIFE.60675

M3 - Article

C2 - 32820721

AN - SCOPUS:85090837873

SN - 2050-084X

VL - 9

SP - 1

EP - 37

JO - eLife

JF - eLife

M1 - e60675

ER -

Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this