TY - JOUR
T1 - Developmental therapeutics for inflammatory breast cancer
T2 - Biology and translational directions
AU - Costa, Ricardo
AU - Santa-Maria, Cesar A.
AU - Rossi, Giovanna
AU - Carneiro, Benedito A.
AU - Chae, Young Kwang
AU - Gradishar, William J.
AU - Giles, Francis J.
AU - Cristofanilli, Massimo
PY - 2017
Y1 - 2017
N2 - Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer, which accounts for approximately 3% of cases of breast malignancies. Diagnosis relies largely on its clinical presentation, and despite a characteristic phenotype, underlying molecular mechanisms are poorly understood. Unique clinical presentation indicates that IBC is a distinct clinical and biological entity when compared to non- IBC. Biological understanding of non-IBC has been extrapolated into IBC and targeted therapies for HER2 positive (HER2+) and hormonal receptor positive non-IBC led to improved patient outcomes in the recent years. This manuscript reviews recent discoveries related to the underlying biology of IBC, clinical progress to date and suggests rational approaches for investigational therapies.
AB - Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer, which accounts for approximately 3% of cases of breast malignancies. Diagnosis relies largely on its clinical presentation, and despite a characteristic phenotype, underlying molecular mechanisms are poorly understood. Unique clinical presentation indicates that IBC is a distinct clinical and biological entity when compared to non- IBC. Biological understanding of non-IBC has been extrapolated into IBC and targeted therapies for HER2 positive (HER2+) and hormonal receptor positive non-IBC led to improved patient outcomes in the recent years. This manuscript reviews recent discoveries related to the underlying biology of IBC, clinical progress to date and suggests rational approaches for investigational therapies.
KW - Immunotherapy
KW - Inflammatory breast cancer
KW - Targeted therapy
UR - https://www.scopus.com/pages/publications/85012935064
U2 - 10.18632/oncotarget.13778
DO - 10.18632/oncotarget.13778
M3 - Review article
C2 - 27926493
AN - SCOPUS:85012935064
SN - 1949-2553
VL - 8
SP - 12417
EP - 12432
JO - Oncotarget
JF - Oncotarget
IS - 7
ER -
