Development of porous and antimicrobial CTS-PEG-HAP-ZnO nano-composites for bone tissue engineering

Arundhati Bhowmick; Nilkamal Pramanik; Piyali Jana Manna; Tapas Mitra; Thirupathi Kumara Raja Selvaraj; Arumugam Gnanamani; Manas Das; Patit Paban Kundu

doi:10.1039/c5ra16755h

Development of porous and antimicrobial CTS-PEG-HAP-ZnO nano-composites for bone tissue engineering

Arundhati Bhowmick
, Nilkamal Pramanik
, Piyali Jana Manna
, Tapas Mitra
, Thirupathi Kumara Raja Selvaraj
, Arumugam Gnanamani
, Manas Das
, Patit Paban Kundu

University of Calcutta
CSIR-Central Leather Research Institute

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

37 Citations (Scopus)

Abstract

Herein, we have developed hybrid nanocomposites of chitosan, poly(ethylene glycol) and nano-hydroxyapatite-zinc oxide with interconnected macroporous structures for bone tissue engineering. These nanocomposites were characterized using different spectroscopic and analytical techniques. The percentage of porosity and the tensile strength of these materials were found to be similar to that of human cancellous bone. Moreover, these hybrid materials exhibited bio-degradability, a neutral pH (7.4) and erythrocyte compatibility. The addition of nano-hydroxyapatite-zinc oxide into the nanocomposites increased the antimicrobial activity and protein adsorption ability. The water uptake ability was found to increase with increasing the proportion of poly(ethylene glycol). Finally, osteoblast-like MG-63 cells were grown, attached and proliferated with these nanocomposites without them having any negative effect and the nanocomposites showed good cytocompatibility.

Original language	English
Pages (from-to)	99385-99393
Number of pages	9
Journal	RSC Advances
Volume	5
Issue number	120
DOIs	https://doi.org/10.1039/c5ra16755h
Publication status	Published - 2015
Externally published	Yes

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10.1039/c5ra16755h

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title = "Development of porous and antimicrobial CTS-PEG-HAP-ZnO nano-composites for bone tissue engineering",

abstract = "Herein, we have developed hybrid nanocomposites of chitosan, poly(ethylene glycol) and nano-hydroxyapatite-zinc oxide with interconnected macroporous structures for bone tissue engineering. These nanocomposites were characterized using different spectroscopic and analytical techniques. The percentage of porosity and the tensile strength of these materials were found to be similar to that of human cancellous bone. Moreover, these hybrid materials exhibited bio-degradability, a neutral pH (7.4) and erythrocyte compatibility. The addition of nano-hydroxyapatite-zinc oxide into the nanocomposites increased the antimicrobial activity and protein adsorption ability. The water uptake ability was found to increase with increasing the proportion of poly(ethylene glycol). Finally, osteoblast-like MG-63 cells were grown, attached and proliferated with these nanocomposites without them having any negative effect and the nanocomposites showed good cytocompatibility.",

author = "Arundhati Bhowmick and Nilkamal Pramanik and Manna, \{Piyali Jana\} and Tapas Mitra and \{Raja Selvaraj\}, \{Thirupathi Kumara\} and Arumugam Gnanamani and Manas Das and Kundu, \{Patit Paban\}",

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year = "2015",

doi = "10.1039/c5ra16755h",

language = "English",

volume = "5",

pages = "99385--99393",

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T1 - Development of porous and antimicrobial CTS-PEG-HAP-ZnO nano-composites for bone tissue engineering

AU - Bhowmick, Arundhati

AU - Pramanik, Nilkamal

AU - Manna, Piyali Jana

AU - Mitra, Tapas

AU - Raja Selvaraj, Thirupathi Kumara

AU - Gnanamani, Arumugam

AU - Das, Manas

AU - Kundu, Patit Paban

PY - 2015

Y1 - 2015

N2 - Herein, we have developed hybrid nanocomposites of chitosan, poly(ethylene glycol) and nano-hydroxyapatite-zinc oxide with interconnected macroporous structures for bone tissue engineering. These nanocomposites were characterized using different spectroscopic and analytical techniques. The percentage of porosity and the tensile strength of these materials were found to be similar to that of human cancellous bone. Moreover, these hybrid materials exhibited bio-degradability, a neutral pH (7.4) and erythrocyte compatibility. The addition of nano-hydroxyapatite-zinc oxide into the nanocomposites increased the antimicrobial activity and protein adsorption ability. The water uptake ability was found to increase with increasing the proportion of poly(ethylene glycol). Finally, osteoblast-like MG-63 cells were grown, attached and proliferated with these nanocomposites without them having any negative effect and the nanocomposites showed good cytocompatibility.

AB - Herein, we have developed hybrid nanocomposites of chitosan, poly(ethylene glycol) and nano-hydroxyapatite-zinc oxide with interconnected macroporous structures for bone tissue engineering. These nanocomposites were characterized using different spectroscopic and analytical techniques. The percentage of porosity and the tensile strength of these materials were found to be similar to that of human cancellous bone. Moreover, these hybrid materials exhibited bio-degradability, a neutral pH (7.4) and erythrocyte compatibility. The addition of nano-hydroxyapatite-zinc oxide into the nanocomposites increased the antimicrobial activity and protein adsorption ability. The water uptake ability was found to increase with increasing the proportion of poly(ethylene glycol). Finally, osteoblast-like MG-63 cells were grown, attached and proliferated with these nanocomposites without them having any negative effect and the nanocomposites showed good cytocompatibility.

UR - https://www.scopus.com/pages/publications/84948455069

U2 - 10.1039/c5ra16755h

DO - 10.1039/c5ra16755h

M3 - Article

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SN - 2046-2069

VL - 5

SP - 99385

EP - 99393

JO - RSC Advances

JF - RSC Advances

IS - 120

ER -

Development of porous and antimicrobial CTS-PEG-HAP-ZnO nano-composites for bone tissue engineering

Abstract

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