Development of an absorption-based tomographic system for mapping the human microvasculature

Paul M. McNamara, Enock Jonathan, Martin J. Leahy

Research output: Chapter in Book or Conference Publication/ProceedingConference Publicationpeer-review

Abstract

There exist numerous planar imaging methods for mapping the human microvasculature. In medical diagnostics, tomography is preferred over surface imaging for the simple reason that biological organs are 3-dimensional in nature. The aim of this work is to create a novel technique to non-invasively map the concentration of red blood cells in the human microcirculation allowing 3-dimensional image reconstruction. We propose a tomographic system which is based on absorption contrast imaging. A Michelson interferometry method is employed using a broadband, white light source. This work details preliminary results of the calibration procedure of a 'bulk' system. A mirror, reflectance standards, glass-mirror arrangement, and color filter arrangement were used as samples. The resultant interference patterns from each were imaged and analyzed.

Original languageEnglish
Title of host publicationDynamics and Fluctuations in Biomedical Photonics VIII
DOIs
Publication statusPublished - 2011
Externally publishedYes
EventDynamics and Fluctuations in Biomedical Photonics VIII - San Francisco, CA, United States
Duration: 22 Jan 201124 Jan 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7898
ISSN (Print)1605-7422

Conference

ConferenceDynamics and Fluctuations in Biomedical Photonics VIII
Country/TerritoryUnited States
CitySan Francisco, CA
Period22/01/1124/01/11

Keywords

  • Absorption
  • Biophotonics
  • Microcirculation
  • Optical imaging
  • Tomography
  • White light interferometry

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