Determination of apparent molar volumes (AMV) and capacity factors (k_w) for sweet and non-sweet sulphamates, correlation between AMV values, and Corey-Pauling-Koltun volumes and relative sweetness correlations

Apparent molar volume (AMV) and apparent specific volume (ASV) have been determined for 16 sulphamates, 14 of which are sweet. Capacity factors (k_w) have been determined by reversed-phase HPLC for seventeen sulphamates. A good linear correlation (r = 0.917, p < 0.001) has been obtained between previously measured Corey-Pauling-Koltun (CPK) volumes and the AMV values of 16 sulphamates. Log k_w values show a moderately high correlation (r = 0.74, p < 0.01) with the logs of the relative sweetness of 12 sulphamates. Relative sweetness also shows a reasonable correlation (r = 0.770, p < 0.01) with molecular connectivity of the third order, ³x_m, for the same 12 compounds. Calculated partition coefficients (log P) for the sulphamates correlate well with log k_w (r = 0.756, p < 0.001).