Design and implementation of in silico clinical trial for Bioresorbable Vascular Scaffolds

Georgia S. Karanasiou; Panagiota I. Tsobou; Nikolaos S. Tachos; Luca Antonini; Lorenza Petrini; Giancarlo Pennati; Frank Gijsen; Farhad Rikhtegar Nezami; Rami Tzafiri; Ted Vaughan; Martin Fawdry; Dimitrios I. Fotiadis

doi:10.1109/EMBC44109.2020.9176317

Design and implementation of in silico clinical trial for Bioresorbable Vascular Scaffolds

Georgia S. Karanasiou
, Panagiota I. Tsobou
, Nikolaos S. Tachos
, Luca Antonini
, Lorenza Petrini
, Giancarlo Pennati
, Frank Gijsen
, Farhad Rikhtegar Nezami
, Rami Tzafiri
, Ted Vaughan
, Martin Fawdry
, Dimitrios I. Fotiadis

Department of Biomedical Research

Research output: Chapter in Book or Conference Publication/Proceeding › Conference Publication › peer-review

5 Citations (Scopus)

Abstract

In the recent years, Bioresorbable Vascular Scaffolds (BVS) for the treatment of atherosclerosis have been introduced. InSilc is a cloud based in silico clinical trial (ISCT) platform for drug-eluting BVS. The platform integrates multidisciplinary and multiscale models predicting the BVS performance. In this study, we present a use case scenario and demonstrate the functioning of the individual modules and of the whole pipeline and the ability to predict BVS short, medium, long-term outcomes.

Original language	English
Title of host publication	42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publication	Enabling Innovative Technologies for Global Healthcare, EMBC 2020
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	2675-2678
Number of pages	4
ISBN (Electronic)	9781728119908
DOIs	https://doi.org/10.1109/EMBC44109.2020.9176317
Publication status	Published - Jul 2020
Externally published	Yes
Event	42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020 - Montreal, Canada Duration: 20 Jul 2020 → 24 Jul 2020

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume	2020-July
ISSN (Print)	1557-170X

Conference

Conference	42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020
Country/Territory	Canada
City	Montreal
Period	20/07/20 → 24/07/20

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10.1109/EMBC44109.2020.9176317

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Karanasiou, G. S., Tsobou, P. I., Tachos, N. S., Antonini, L., Petrini, L., Pennati, G., Gijsen, F., Nezami, F. R., Tzafiri, R., Vaughan, T., Fawdry, M., & Fotiadis, D. I. (2020). Design and implementation of in silico clinical trial for Bioresorbable Vascular Scaffolds. In 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020 (pp. 2675-2678). Article 9176317 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2020-July). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC44109.2020.9176317

Karanasiou, Georgia S. ; Tsobou, Panagiota I. ; Tachos, Nikolaos S. et al. / Design and implementation of in silico clinical trial for Bioresorbable Vascular Scaffolds. 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020. Institute of Electrical and Electronics Engineers Inc., 2020. pp. 2675-2678 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

@inproceedings{3b820e2d0e7f4638a0d72f45201680e9,

title = "Design and implementation of in silico clinical trial for Bioresorbable Vascular Scaffolds",

abstract = "In the recent years, Bioresorbable Vascular Scaffolds (BVS) for the treatment of atherosclerosis have been introduced. InSilc is a cloud based in silico clinical trial (ISCT) platform for drug-eluting BVS. The platform integrates multidisciplinary and multiscale models predicting the BVS performance. In this study, we present a use case scenario and demonstrate the functioning of the individual modules and of the whole pipeline and the ability to predict BVS short, medium, long-term outcomes.",

author = "Karanasiou, \{Georgia S.\} and Tsobou, \{Panagiota I.\} and Tachos, \{Nikolaos S.\} and Luca Antonini and Lorenza Petrini and Giancarlo Pennati and Frank Gijsen and Nezami, \{Farhad Rikhtegar\} and Rami Tzafiri and Ted Vaughan and Martin Fawdry and Fotiadis, \{Dimitrios I.\}",

note = "Publisher Copyright: {\textcopyright} 2020 IEEE.; 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020 ; Conference date: 20-07-2020 Through 24-07-2020",

year = "2020",

month = jul,

doi = "10.1109/EMBC44109.2020.9176317",

language = "English",

series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "2675--2678",

booktitle = "42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society",

}

Karanasiou, GS, Tsobou, PI, Tachos, NS, Antonini, L, Petrini, L, Pennati, G, Gijsen, F, Nezami, FR, Tzafiri, R, Vaughan, T, Fawdry, M & Fotiadis, DI 2020, Design and implementation of in silico clinical trial for Bioresorbable Vascular Scaffolds. in 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020., 9176317, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2020-July, Institute of Electrical and Electronics Engineers Inc., pp. 2675-2678, 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020, Montreal, Canada, 20/07/20. https://doi.org/10.1109/EMBC44109.2020.9176317

Design and implementation of in silico clinical trial for Bioresorbable Vascular Scaffolds. / Karanasiou, Georgia S.; Tsobou, Panagiota I.; Tachos, Nikolaos S. et al.
42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020. Institute of Electrical and Electronics Engineers Inc., 2020. p. 2675-2678 9176317 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2020-July).

Research output: Chapter in Book or Conference Publication/Proceeding › Conference Publication › peer-review

TY - GEN

T1 - Design and implementation of in silico clinical trial for Bioresorbable Vascular Scaffolds

AU - Karanasiou, Georgia S.

AU - Tsobou, Panagiota I.

AU - Tachos, Nikolaos S.

AU - Antonini, Luca

AU - Petrini, Lorenza

AU - Pennati, Giancarlo

AU - Gijsen, Frank

AU - Nezami, Farhad Rikhtegar

AU - Tzafiri, Rami

AU - Vaughan, Ted

AU - Fawdry, Martin

AU - Fotiadis, Dimitrios I.

PY - 2020/7

Y1 - 2020/7

N2 - In the recent years, Bioresorbable Vascular Scaffolds (BVS) for the treatment of atherosclerosis have been introduced. InSilc is a cloud based in silico clinical trial (ISCT) platform for drug-eluting BVS. The platform integrates multidisciplinary and multiscale models predicting the BVS performance. In this study, we present a use case scenario and demonstrate the functioning of the individual modules and of the whole pipeline and the ability to predict BVS short, medium, long-term outcomes.

AB - In the recent years, Bioresorbable Vascular Scaffolds (BVS) for the treatment of atherosclerosis have been introduced. InSilc is a cloud based in silico clinical trial (ISCT) platform for drug-eluting BVS. The platform integrates multidisciplinary and multiscale models predicting the BVS performance. In this study, we present a use case scenario and demonstrate the functioning of the individual modules and of the whole pipeline and the ability to predict BVS short, medium, long-term outcomes.

UR - https://www.scopus.com/pages/publications/85091041216

U2 - 10.1109/EMBC44109.2020.9176317

DO - 10.1109/EMBC44109.2020.9176317

M3 - Conference Publication

AN - SCOPUS:85091041216

T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

SP - 2675

EP - 2678

BT - 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020

Y2 - 20 July 2020 through 24 July 2020

ER -

Karanasiou GS, Tsobou PI, Tachos NS, Antonini L, Petrini L, Pennati G et al. Design and implementation of in silico clinical trial for Bioresorbable Vascular Scaffolds. In 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020. Institute of Electrical and Electronics Engineers Inc. 2020. p. 2675-2678. 9176317. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC44109.2020.9176317

Design and implementation of in silico clinical trial for Bioresorbable Vascular Scaffolds

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