Depth-dependent displacement sensitivity analysis and the influence of Doppler angle for quantitative assessment of mechanical properties using phase-sensitive spectral domain optical coherence tomography

Gillian Lynch, Hrebesh Subhash, Sergey Alexandrov, Martin Leahy

Research output: Chapter in Book or Conference Publication/ProceedingConference Publicationpeer-review

Abstract

Optical coherence elastography (OCE) asesses the mechanical properties of samples by applying a mechanical stimulation and detecting the resulting sample displacement using optical coherence tomography (OCT). OCE methods which utilise the phase of the OCT signal offer the potential to detect displacements on the sub-nanometre scale. However, the displacement sensitivity achieveable is directly related to the signal-to-noise ratio and phase stability of the underlying OCT system. Furthermore, the estimation of Doppler angle is imperative in accurately measuring the sample displacement. This work evaluates the contributions of each of these parameters for quantitative assessment of mechanical properties using phase-sensitive spectral domain OCT.

Original languageEnglish
Title of host publicationOptical Elastography and Tissue Biomechanics III
EditorsDavid D. Sampson, Kirill V. Larin
PublisherSPIE
ISBN (Electronic)9781628419443
DOIs
Publication statusPublished - 2016
EventOptical Elastography and Tissue Biomechanics III - San Francisco, United States
Duration: 13 Feb 201615 Feb 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9710
ISSN (Print)1605-7422

Conference

ConferenceOptical Elastography and Tissue Biomechanics III
Country/TerritoryUnited States
CitySan Francisco
Period13/02/1615/02/16

Keywords

  • Doppler angle
  • Optical coherence tomography
  • biomechanics
  • elastography
  • phase measurements
  • scattering
  • tissue characterization

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