Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor

Paul Murphy; EVA ERZSEBET SZEGEZDI

doi:http://hdl.handle.net/10379/5380

Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

Abstract

A build-couple-pair strategy, including double-reductive amination macrocyclization, has been used to generate decorated macrocycles (eannaphanes) with an embedded triazole and monosaccharide. Biological screening led to the identification of an inducer of apoptosis in leukemic cells, which acts at least partially as a 5-HT2 antagonist.

Original language	English (Ireland)
Number of pages	4
Journal	Organic Letters
Volume	17
DOIs	https://doi.org/http://hdl.handle.net/10379/5380
Publication status	Published - 1 Apr 2015

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Zhou, J,Reidy, M,O'Reilly, C,Jarikote, DV,Negi, A,Samali, A,Szegezdi, E,Murphy, PV

Access to Document

http://hdl.handle.net/10379/5380

Cite this

@article{239cdc439d0e45dcb5bfc4a11ea76c21,

title = "Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor",

abstract = "A build-couple-pair strategy, including double-reductive amination macrocyclization, has been used to generate decorated macrocycles (eannaphanes) with an embedded triazole and monosaccharide. Biological screening led to the identification of an inducer of apoptosis in leukemic cells, which acts at least partially as a 5-HT2 antagonist.",

author = "Paul Murphy and SZEGEZDI, \{EVA ERZSEBET\}",

year = "2015",

month = apr,

day = "1",

doi = "http://hdl.handle.net/10379/5380",

language = "English (Ireland)",

volume = "17",

journal = "Organic Letters",

}

TY - JOUR

T1 - Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor

AU - Murphy, Paul

AU - SZEGEZDI, EVA ERZSEBET

PY - 2015/4/1

Y1 - 2015/4/1

N2 - A build-couple-pair strategy, including double-reductive amination macrocyclization, has been used to generate decorated macrocycles (eannaphanes) with an embedded triazole and monosaccharide. Biological screening led to the identification of an inducer of apoptosis in leukemic cells, which acts at least partially as a 5-HT2 antagonist.

AB - A build-couple-pair strategy, including double-reductive amination macrocyclization, has been used to generate decorated macrocycles (eannaphanes) with an embedded triazole and monosaccharide. Biological screening led to the identification of an inducer of apoptosis in leukemic cells, which acts at least partially as a 5-HT2 antagonist.

U2 - http://hdl.handle.net/10379/5380

DO - http://hdl.handle.net/10379/5380

M3 - Article

VL - 17

JO - Organic Letters

JF - Organic Letters

ER -

Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor

Abstract

Authors (Note for portal: view the doc link for the full list of authors)

Access to Document

Fingerprint

Cite this