TY - JOUR
T1 - Cytotoxicity and antimicrobial activity of triorganotin(IV) complexes of phenylcyanamide prepared by sonochemical synthesis
AU - Tabrizi, Leila
AU - Mcardle, Patrick
AU - Erxleben, Andrea
AU - Chiniforoshan, Hossein
N1 - Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - This article describes the synthesis and characterization of novel triorganotin(IV) complexes and their potential medicinal applications. Triorganotin(IV) complexes with formulas [(SnMe3)2(μ-bp)(H2O)2], 1, and [(SnMe3)(4-NO2pcyd)], 2, (Me: methyl, bpH2: 4,4′-dicyanamidobiphenyl and 4-NO2pcyd: 4-nitrophenylcyanamide) have been synthesized via a sonochemical process and characterized using multinuclear NMR (1H, 13C and 119Sn), Mössbauer spectroscopy, elemental analysis, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Compounds 1 and 2 were evaluated for their DNA/protein binding with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA), respectively. The in vitro cytotoxicity of 1 and 2 was examined against A549, Du145, HeLa and MCF-7 cancer cell lines. For 1, a promising growth inhibitory effect against HeLa cells was observed that is slightly higher than that of cisplatin. Moreover, the antimicrobial activity of 1 and 2 against different strains of pathogenic bacteria and fungi were tested. The free radical scavenging ability (OH, NO) of 1 and 2 was assessed.
AB - This article describes the synthesis and characterization of novel triorganotin(IV) complexes and their potential medicinal applications. Triorganotin(IV) complexes with formulas [(SnMe3)2(μ-bp)(H2O)2], 1, and [(SnMe3)(4-NO2pcyd)], 2, (Me: methyl, bpH2: 4,4′-dicyanamidobiphenyl and 4-NO2pcyd: 4-nitrophenylcyanamide) have been synthesized via a sonochemical process and characterized using multinuclear NMR (1H, 13C and 119Sn), Mössbauer spectroscopy, elemental analysis, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Compounds 1 and 2 were evaluated for their DNA/protein binding with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA), respectively. The in vitro cytotoxicity of 1 and 2 was examined against A549, Du145, HeLa and MCF-7 cancer cell lines. For 1, a promising growth inhibitory effect against HeLa cells was observed that is slightly higher than that of cisplatin. Moreover, the antimicrobial activity of 1 and 2 against different strains of pathogenic bacteria and fungi were tested. The free radical scavenging ability (OH, NO) of 1 and 2 was assessed.
KW - Antioxidant activity
KW - BSA binding
KW - Cytotoxicity
KW - DNA binding
KW - Triorganotin phenylcyanamide
UR - https://www.scopus.com/pages/publications/84942847800
U2 - 10.1016/j.ica.2015.09.011
DO - 10.1016/j.ica.2015.09.011
M3 - Article
SN - 0020-1693
VL - 438
SP - 94
EP - 104
JO - Inorganica Chimica Acta
JF - Inorganica Chimica Acta
ER -
