Cysteine proteases during larval migration and development of helminths in their final host

Alexandra Grote; Conor R. Caffrey; Karina M. Rebello; David Smith; John P. Dalton; Sara Lustigman

doi:10.1371/journal.pntd.0005919

Cysteine proteases during larval migration and development of helminths in their final host

Alexandra Grote
, Conor R. Caffrey
, Karina M. Rebello
, David Smith
, John P. Dalton
, Sara Lustigman

New York University
University of California San Diego
Laboratory of Pathology and Biointervention
Queen's University of Belfast
University of Michigan Medical School
New York Blood Center

Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review

30 Citations (Scopus)

Abstract

Neglected tropical diseases caused by metazoan parasites are major public health concerns, and therefore, new methods for their control and elimination are needed. Research over the last 25 years has revealed the vital contribution of cysteine proteases to invasion of and migration by (larval) helminth parasites through host tissues, in addition to their roles in embryogenesis, molting, egg hatching, and yolk degradation. Their central function to maintaining parasite survival in the host has made them prime intervention targets for novel drugs and vaccines. This review focuses on those helminth cysteine proteases that have been functionally characterized during the varied early stages of development in the human host and embryogenesis.

Original language	English
Article number	e0005919
Journal	PLoS Neglected Tropical Diseases
Volume	12
Issue number	8
DOIs	https://doi.org/10.1371/journal.pntd.0005919
Publication status	Published - Aug 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1371/journal.pntd.0005919

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title = "Cysteine proteases during larval migration and development of helminths in their final host",

abstract = "Neglected tropical diseases caused by metazoan parasites are major public health concerns, and therefore, new methods for their control and elimination are needed. Research over the last 25 years has revealed the vital contribution of cysteine proteases to invasion of and migration by (larval) helminth parasites through host tissues, in addition to their roles in embryogenesis, molting, egg hatching, and yolk degradation. Their central function to maintaining parasite survival in the host has made them prime intervention targets for novel drugs and vaccines. This review focuses on those helminth cysteine proteases that have been functionally characterized during the varied early stages of development in the human host and embryogenesis.",

author = "Alexandra Grote and Caffrey, \{Conor R.\} and Rebello, \{Karina M.\} and David Smith and Dalton, \{John P.\} and Sara Lustigman",

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language = "English",

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AU - Grote, Alexandra

AU - Caffrey, Conor R.

AU - Rebello, Karina M.

AU - Smith, David

AU - Dalton, John P.

AU - Lustigman, Sara

PY - 2018/8

Y1 - 2018/8

N2 - Neglected tropical diseases caused by metazoan parasites are major public health concerns, and therefore, new methods for their control and elimination are needed. Research over the last 25 years has revealed the vital contribution of cysteine proteases to invasion of and migration by (larval) helminth parasites through host tissues, in addition to their roles in embryogenesis, molting, egg hatching, and yolk degradation. Their central function to maintaining parasite survival in the host has made them prime intervention targets for novel drugs and vaccines. This review focuses on those helminth cysteine proteases that have been functionally characterized during the varied early stages of development in the human host and embryogenesis.

AB - Neglected tropical diseases caused by metazoan parasites are major public health concerns, and therefore, new methods for their control and elimination are needed. Research over the last 25 years has revealed the vital contribution of cysteine proteases to invasion of and migration by (larval) helminth parasites through host tissues, in addition to their roles in embryogenesis, molting, egg hatching, and yolk degradation. Their central function to maintaining parasite survival in the host has made them prime intervention targets for novel drugs and vaccines. This review focuses on those helminth cysteine proteases that have been functionally characterized during the varied early stages of development in the human host and embryogenesis.

UR - https://www.scopus.com/pages/publications/85054848389

U2 - 10.1371/journal.pntd.0005919

DO - 10.1371/journal.pntd.0005919

M3 - Review article

C2 - 30138448

AN - SCOPUS:85054848389

SN - 1935-2727

VL - 12

JO - PLoS Neglected Tropical Diseases

JF - PLoS Neglected Tropical Diseases

IS - 8

M1 - e0005919

ER -

Cysteine proteases during larval migration and development of helminths in their final host

Abstract

UN SDGs

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