Cysteine proteases during larval migration and development of helminths in their final host

Alexandra Grote; Conor R. Caffrey; Karina M. Rebello; David Smith; John P. Dalton; Sara Lustigman

doi:10.1371/journal.pntd.0005919

Cysteine proteases during larval migration and development of helminths in their final host

Alexandra Grote, Conor R. Caffrey, Karina M. Rebello, David Smith, John P. Dalton, Sara Lustigman

Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review

28 Citations (Scopus)

Abstract

Neglected tropical diseases caused by metazoan parasites are major public health concerns, and therefore, new methods for their control and elimination are needed. Research over the last 25 years has revealed the vital contribution of cysteine proteases to invasion of and migration by (larval) helminth parasites through host tissues, in addition to their roles in embryogenesis, molting, egg hatching, and yolk degradation. Their central function to maintaining parasite survival in the host has made them prime intervention targets for novel drugs and vaccines. This review focuses on those helminth cysteine proteases that have been functionally characterized during the varied early stages of development in the human host and embryogenesis.

Original language	English
Article number	e0005919
Journal	PLoS Neglected Tropical Diseases
Volume	12
Issue number	8
DOIs	https://doi.org/10.1371/journal.pntd.0005919
Publication status	Published - Aug 2018
Externally published	Yes

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10.1371/journal.pntd.0005919

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title = "Cysteine proteases during larval migration and development of helminths in their final host",

abstract = "Neglected tropical diseases caused by metazoan parasites are major public health concerns, and therefore, new methods for their control and elimination are needed. Research over the last 25 years has revealed the vital contribution of cysteine proteases to invasion of and migration by (larval) helminth parasites through host tissues, in addition to their roles in embryogenesis, molting, egg hatching, and yolk degradation. Their central function to maintaining parasite survival in the host has made them prime intervention targets for novel drugs and vaccines. This review focuses on those helminth cysteine proteases that have been functionally characterized during the varied early stages of development in the human host and embryogenesis.",

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AU - Grote, Alexandra

AU - Caffrey, Conor R.

AU - Rebello, Karina M.

AU - Smith, David

AU - Dalton, John P.

AU - Lustigman, Sara

PY - 2018/8

Y1 - 2018/8

N2 - Neglected tropical diseases caused by metazoan parasites are major public health concerns, and therefore, new methods for their control and elimination are needed. Research over the last 25 years has revealed the vital contribution of cysteine proteases to invasion of and migration by (larval) helminth parasites through host tissues, in addition to their roles in embryogenesis, molting, egg hatching, and yolk degradation. Their central function to maintaining parasite survival in the host has made them prime intervention targets for novel drugs and vaccines. This review focuses on those helminth cysteine proteases that have been functionally characterized during the varied early stages of development in the human host and embryogenesis.

AB - Neglected tropical diseases caused by metazoan parasites are major public health concerns, and therefore, new methods for their control and elimination are needed. Research over the last 25 years has revealed the vital contribution of cysteine proteases to invasion of and migration by (larval) helminth parasites through host tissues, in addition to their roles in embryogenesis, molting, egg hatching, and yolk degradation. Their central function to maintaining parasite survival in the host has made them prime intervention targets for novel drugs and vaccines. This review focuses on those helminth cysteine proteases that have been functionally characterized during the varied early stages of development in the human host and embryogenesis.

UR - https://www.scopus.com/pages/publications/85054848389

U2 - 10.1371/journal.pntd.0005919

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M3 - Review article

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AN - SCOPUS:85054848389

SN - 1935-2727

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JO - PLoS Neglected Tropical Diseases

JF - PLoS Neglected Tropical Diseases

IS - 8

M1 - e0005919

ER -

Cysteine proteases during larval migration and development of helminths in their final host

Abstract

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