Cross-resistance analysis for DU-6859a, a new fluoroquinolone, compared to six structurally similar compounds (ciprofloxacin, clinafloxacin, fleroxacin, levofloxacin, ofloxacin, and sparfloxacin)

Martin G. Cormican; Steven A. Marshall; Ronald N. Jones

doi:10.1016/0732-8893(94)00116-E

Cross-resistance analysis for DU-6859a, a new fluoroquinolone, compared to six structurally similar compounds (ciprofloxacin, clinafloxacin, fleroxacin, levofloxacin, ofloxacin, and sparfloxacin)

Martin G. Cormican
, Steven A. Marshall
, Ronald N. Jones

University of Iowa Carver College of Medicine

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

13 Citations (Scopus)

Abstract

Emerging resistance to the current fluoroquinolones has encouraged synthesis of new compounds in this class. We have evaluated the activity of DU-6859a, a novel halogenated quinolone, against a panel of 300 bacteria, relative to the activity of ciprofloxacin, clinafloxacin, fleroxacin, levofloxacin, ofloxacin, and sparfloxacin. DU-6859a was the most active of the fluoroquinolones studied and retains potentially useful activity against 80% of isolates resistant (minimum inhibitory concentration, ≥4 μg/ml) to ciprofloxacin. Continued clinical investigation of DU-6859a and similar new quinolones is urged.

Original language	English
Pages (from-to)	51-54
Number of pages	4
Journal	Diagnostic Microbiology and Infectious Disease
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/0732-8893(94)00116-E
Publication status	Published - Jan 1995
Externally published	Yes

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10.1016/0732-8893(94)00116-E

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title = "Cross-resistance analysis for DU-6859a, a new fluoroquinolone, compared to six structurally similar compounds (ciprofloxacin, clinafloxacin, fleroxacin, levofloxacin, ofloxacin, and sparfloxacin)",

abstract = "Emerging resistance to the current fluoroquinolones has encouraged synthesis of new compounds in this class. We have evaluated the activity of DU-6859a, a novel halogenated quinolone, against a panel of 300 bacteria, relative to the activity of ciprofloxacin, clinafloxacin, fleroxacin, levofloxacin, ofloxacin, and sparfloxacin. DU-6859a was the most active of the fluoroquinolones studied and retains potentially useful activity against 80\% of isolates resistant (minimum inhibitory concentration, ≥4 μg/ml) to ciprofloxacin. Continued clinical investigation of DU-6859a and similar new quinolones is urged.",

author = "Cormican, \{Martin G.\} and Marshall, \{Steven A.\} and Jones, \{Ronald N.\}",

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Cross-resistance analysis for DU-6859a, a new fluoroquinolone, compared to six structurally similar compounds (ciprofloxacin, clinafloxacin, fleroxacin, levofloxacin, ofloxacin, and sparfloxacin). / Cormican, Martin G.; Marshall, Steven A.; Jones, Ronald N.
In: Diagnostic Microbiology and Infectious Disease, Vol. 21, No. 1, 01.1995, p. 51-54.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

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AU - Marshall, Steven A.

AU - Jones, Ronald N.

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AB - Emerging resistance to the current fluoroquinolones has encouraged synthesis of new compounds in this class. We have evaluated the activity of DU-6859a, a novel halogenated quinolone, against a panel of 300 bacteria, relative to the activity of ciprofloxacin, clinafloxacin, fleroxacin, levofloxacin, ofloxacin, and sparfloxacin. DU-6859a was the most active of the fluoroquinolones studied and retains potentially useful activity against 80% of isolates resistant (minimum inhibitory concentration, ≥4 μg/ml) to ciprofloxacin. Continued clinical investigation of DU-6859a and similar new quinolones is urged.

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Cross-resistance analysis for DU-6859a, a new fluoroquinolone, compared to six structurally similar compounds (ciprofloxacin, clinafloxacin, fleroxacin, levofloxacin, ofloxacin, and sparfloxacin)

Abstract

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