TY - JOUR
T1 - Cross-resistance analysis for DU-6859a, a new fluoroquinolone, compared to six structurally similar compounds (ciprofloxacin, clinafloxacin, fleroxacin, levofloxacin, ofloxacin, and sparfloxacin)
AU - Cormican, Martin G.
AU - Marshall, Steven A.
AU - Jones, Ronald N.
PY - 1995/1
Y1 - 1995/1
N2 - Emerging resistance to the current fluoroquinolones has encouraged synthesis of new compounds in this class. We have evaluated the activity of DU-6859a, a novel halogenated quinolone, against a panel of 300 bacteria, relative to the activity of ciprofloxacin, clinafloxacin, fleroxacin, levofloxacin, ofloxacin, and sparfloxacin. DU-6859a was the most active of the fluoroquinolones studied and retains potentially useful activity against 80% of isolates resistant (minimum inhibitory concentration, ≥4 μg/ml) to ciprofloxacin. Continued clinical investigation of DU-6859a and similar new quinolones is urged.
AB - Emerging resistance to the current fluoroquinolones has encouraged synthesis of new compounds in this class. We have evaluated the activity of DU-6859a, a novel halogenated quinolone, against a panel of 300 bacteria, relative to the activity of ciprofloxacin, clinafloxacin, fleroxacin, levofloxacin, ofloxacin, and sparfloxacin. DU-6859a was the most active of the fluoroquinolones studied and retains potentially useful activity against 80% of isolates resistant (minimum inhibitory concentration, ≥4 μg/ml) to ciprofloxacin. Continued clinical investigation of DU-6859a and similar new quinolones is urged.
UR - https://www.scopus.com/pages/publications/0028966916
U2 - 10.1016/0732-8893(94)00116-E
DO - 10.1016/0732-8893(94)00116-E
M3 - Article
C2 - 7789097
AN - SCOPUS:0028966916
SN - 0732-8893
VL - 21
SP - 51
EP - 54
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 1
ER -