Correlation of GDF5 and Connexin 43 mRNA Expression during Embryonic Development

Cynthia M. Coleman; Grace A. Loredo; Cecilia W. Lo; Rocky S. Tuan

doi:10.1002/ar.a.10125

Correlation of GDF5 and Connexin 43 mRNA Expression during Embryonic Development

Cynthia M. Coleman, Grace A. Loredo, Cecilia W. Lo, Rocky S. Tuan

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

27 Citations (Scopus)

Abstract

Growth/differentiation factor 5 (GDF5) regulates connexin expression and enhances embryonic chondrogenesis in a gap junction-dependent manner, suggesting that GDF5 action on developmental skeletogenesis is coordinated with gap junction activities. The results shown here demonstrate concordance between the mRNA expression profiles of GDF5 and the gap junction gene, Cx43, in the mouse embryonic limb, spine, and heart, consistent with coordinated functions for these gene products during developmental organogenesis.

Original language	English
Pages (from-to)	1117-1121
Number of pages	5
Journal	Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology
Volume	275
Issue number	2
DOIs	https://doi.org/10.1002/ar.a.10125
Publication status	Published - Dec 2003
Externally published	Yes

Keywords

Chondrogenesis
Connexin 43
Growth/differentiation factor 5
Heart development
Spine development
Tendon development

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10.1002/ar.a.10125

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title = "Correlation of GDF5 and Connexin 43 mRNA Expression during Embryonic Development",

abstract = "Growth/differentiation factor 5 (GDF5) regulates connexin expression and enhances embryonic chondrogenesis in a gap junction-dependent manner, suggesting that GDF5 action on developmental skeletogenesis is coordinated with gap junction activities. The results shown here demonstrate concordance between the mRNA expression profiles of GDF5 and the gap junction gene, Cx43, in the mouse embryonic limb, spine, and heart, consistent with coordinated functions for these gene products during developmental organogenesis.",

keywords = "Chondrogenesis, Connexin 43, Growth/differentiation factor 5, Heart development, Spine development, Tendon development",

author = "Coleman, \{Cynthia M.\} and Loredo, \{Grace A.\} and Lo, \{Cecilia W.\} and Tuan, \{Rocky S.\}",

year = "2003",

month = dec,

doi = "10.1002/ar.a.10125",

language = "English",

volume = "275",

pages = "1117--1121",

journal = "Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology",

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publisher = "John Wiley \& Sons Inc.",

number = "2",

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TY - JOUR

T1 - Correlation of GDF5 and Connexin 43 mRNA Expression during Embryonic Development

AU - Coleman, Cynthia M.

AU - Loredo, Grace A.

AU - Lo, Cecilia W.

AU - Tuan, Rocky S.

PY - 2003/12

Y1 - 2003/12

N2 - Growth/differentiation factor 5 (GDF5) regulates connexin expression and enhances embryonic chondrogenesis in a gap junction-dependent manner, suggesting that GDF5 action on developmental skeletogenesis is coordinated with gap junction activities. The results shown here demonstrate concordance between the mRNA expression profiles of GDF5 and the gap junction gene, Cx43, in the mouse embryonic limb, spine, and heart, consistent with coordinated functions for these gene products during developmental organogenesis.

AB - Growth/differentiation factor 5 (GDF5) regulates connexin expression and enhances embryonic chondrogenesis in a gap junction-dependent manner, suggesting that GDF5 action on developmental skeletogenesis is coordinated with gap junction activities. The results shown here demonstrate concordance between the mRNA expression profiles of GDF5 and the gap junction gene, Cx43, in the mouse embryonic limb, spine, and heart, consistent with coordinated functions for these gene products during developmental organogenesis.

KW - Chondrogenesis

KW - Connexin 43

KW - Growth/differentiation factor 5

KW - Heart development

KW - Spine development

KW - Tendon development

UR - https://www.scopus.com/pages/publications/0345258017

U2 - 10.1002/ar.a.10125

DO - 10.1002/ar.a.10125

M3 - Article

SN - 0003-276X

VL - 275

SP - 1117

EP - 1121

JO - Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology

JF - Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology

IS - 2

ER -

Correlation of GDF5 and Connexin 43 mRNA Expression during Embryonic Development

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Keywords

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