Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal Stenosis

Tjun Y. Tang; Simon P.S. Howarth; Sam R. Miller; Martin J. Graves; Jean Marie U-King-Im; Zhi Yong Li; Stewart R. Walsh; Andrew J. Patterson; Peter J. Kirkpatrick; Elizabeth A. Warburton; Kevin Varty; Michael E. Gaunt; Jonathan H. Gillard

doi:10.1161/STROKEAHA.107.504753

Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal Stenosis

Tjun Y. Tang
, Simon P.S. Howarth
, Sam R. Miller
, Martin J. Graves
, Jean Marie U-King-Im
, Zhi Yong Li
, Stewart R. Walsh
, Andrew J. Patterson
, Peter J. Kirkpatrick
, Elizabeth A. Warburton
, Kevin Varty
, Michael E. Gaunt
, Jonathan H. Gillard

Cambridge University Hospitals NHS Foundation Trust
GlaxoSmithKline plc.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

57 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE-Inflammation is a recognized risk factor for the vulnerable atherosclerotic plaque. The study explores the relationship between the degree of Magnetic Resonance (MR)"defined inflammation using Ultra Small Super-Paramagnetic Iron Oxide (USPIO) particles and the severity of luminal stenosis in asymptomatic carotid plaques. METHODS-Seventy-one patients with an asymptomatic carotid stenosis of ĝ‰¥40% underwent multi-sequence USPIO-enhanced MR imaging. Stenosis severity was measured according to the NASCET and ECST methods. RESULTS-No demonstrable relationship between inflammation as measured by USPIO-enhanced signal change and the degree of luminal stenosis was found. CONCLUSIONS-Inflammation and stenosis are likely to be independent risk factors, although this needs to be further validated.

Original language	English
Pages (from-to)	2144-2147
Number of pages	4
Journal	Stroke
Volume	39
Issue number	7
DOIs	https://doi.org/10.1161/STROKEAHA.107.504753
Publication status	Published - 1 Jul 2008
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Asymptomatic carotid stenosis
Atherosclerosis
Inflammation
MRI
Plaque vulnerability
USPIO

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10.1161/STROKEAHA.107.504753

Cite this

Tang, T. Y., Howarth, S. P. S., Miller, S. R., Graves, M. J., U-King-Im, J. M., Li, Z. Y., Walsh, S. R., Patterson, A. J., Kirkpatrick, P. J., Warburton, E. A., Varty, K., Gaunt, M. E., & Gillard, J. H. (2008). Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal Stenosis. Stroke, 39(7), 2144-2147. https://doi.org/10.1161/STROKEAHA.107.504753

@article{3573dee448494481ac1dad5b2fba0734,

title = "Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal Stenosis",

abstract = "BACKGROUND AND PURPOSE-Inflammation is a recognized risk factor for the vulnerable atherosclerotic plaque. The study explores the relationship between the degree of Magnetic Resonance (MR){"}defined inflammation using Ultra Small Super-Paramagnetic Iron Oxide (USPIO) particles and the severity of luminal stenosis in asymptomatic carotid plaques. METHODS-Seventy-one patients with an asymptomatic carotid stenosis of ĝ‰¥40\% underwent multi-sequence USPIO-enhanced MR imaging. Stenosis severity was measured according to the NASCET and ECST methods. RESULTS-No demonstrable relationship between inflammation as measured by USPIO-enhanced signal change and the degree of luminal stenosis was found. CONCLUSIONS-Inflammation and stenosis are likely to be independent risk factors, although this needs to be further validated.",

keywords = "Asymptomatic carotid stenosis, Atherosclerosis, Inflammation, MRI, Plaque vulnerability, USPIO",

author = "Tang, \{Tjun Y.\} and Howarth, \{Simon P.S.\} and Miller, \{Sam R.\} and Graves, \{Martin J.\} and U-King-Im, \{Jean Marie\} and Li, \{Zhi Yong\} and Walsh, \{Stewart R.\} and Patterson, \{Andrew J.\} and Kirkpatrick, \{Peter J.\} and Warburton, \{Elizabeth A.\} and Kevin Varty and Gaunt, \{Michael E.\} and Gillard, \{Jonathan H.\}",

year = "2008",

month = jul,

day = "1",

doi = "10.1161/STROKEAHA.107.504753",

language = "English",

volume = "39",

pages = "2144--2147",

journal = "Stroke",

issn = "0039-2499",

publisher = "Wolters Kluwer Health",

number = "7",

}

Tang, TY, Howarth, SPS, Miller, SR, Graves, MJ, U-King-Im, JM, Li, ZY, Walsh, SR, Patterson, AJ, Kirkpatrick, PJ, Warburton, EA, Varty, K, Gaunt, ME & Gillard, JH 2008, 'Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal Stenosis', Stroke, vol. 39, no. 7, pp. 2144-2147. https://doi.org/10.1161/STROKEAHA.107.504753

TY - JOUR

T1 - Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal Stenosis

AU - Tang, Tjun Y.

AU - Howarth, Simon P.S.

AU - Miller, Sam R.

AU - Graves, Martin J.

AU - U-King-Im, Jean Marie

AU - Li, Zhi Yong

AU - Walsh, Stewart R.

AU - Patterson, Andrew J.

AU - Kirkpatrick, Peter J.

AU - Warburton, Elizabeth A.

AU - Varty, Kevin

AU - Gaunt, Michael E.

AU - Gillard, Jonathan H.

PY - 2008/7/1

Y1 - 2008/7/1

N2 - BACKGROUND AND PURPOSE-Inflammation is a recognized risk factor for the vulnerable atherosclerotic plaque. The study explores the relationship between the degree of Magnetic Resonance (MR)"defined inflammation using Ultra Small Super-Paramagnetic Iron Oxide (USPIO) particles and the severity of luminal stenosis in asymptomatic carotid plaques. METHODS-Seventy-one patients with an asymptomatic carotid stenosis of ĝ‰¥40% underwent multi-sequence USPIO-enhanced MR imaging. Stenosis severity was measured according to the NASCET and ECST methods. RESULTS-No demonstrable relationship between inflammation as measured by USPIO-enhanced signal change and the degree of luminal stenosis was found. CONCLUSIONS-Inflammation and stenosis are likely to be independent risk factors, although this needs to be further validated.

AB - BACKGROUND AND PURPOSE-Inflammation is a recognized risk factor for the vulnerable atherosclerotic plaque. The study explores the relationship between the degree of Magnetic Resonance (MR)"defined inflammation using Ultra Small Super-Paramagnetic Iron Oxide (USPIO) particles and the severity of luminal stenosis in asymptomatic carotid plaques. METHODS-Seventy-one patients with an asymptomatic carotid stenosis of ĝ‰¥40% underwent multi-sequence USPIO-enhanced MR imaging. Stenosis severity was measured according to the NASCET and ECST methods. RESULTS-No demonstrable relationship between inflammation as measured by USPIO-enhanced signal change and the degree of luminal stenosis was found. CONCLUSIONS-Inflammation and stenosis are likely to be independent risk factors, although this needs to be further validated.

KW - Asymptomatic carotid stenosis

KW - Atherosclerosis

KW - Inflammation

KW - MRI

KW - Plaque vulnerability

KW - USPIO

UR - https://www.scopus.com/pages/publications/47649104588

U2 - 10.1161/STROKEAHA.107.504753

DO - 10.1161/STROKEAHA.107.504753

M3 - Article

SN - 0039-2499

VL - 39

SP - 2144

EP - 2147

JO - Stroke

JF - Stroke

IS - 7

ER -

Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal Stenosis

Abstract

UN SDGs

Keywords

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