TY - JOUR
T1 - Correlates of non-target vessel-related adverse events in patients with ST-segment elevation myocardial infarction
T2 - Insights from five-year follow-up of the EXAMINATION trial
AU - Spitaleri, Giosafat
AU - Moscarella, Elisabetta
AU - Brugaletta, Salvatore
AU - Pernigotti, Alberto
AU - Ortega-Paz, Luis
AU - Gomez-Lara, Josep
AU - Cequier, Angel
AU - Iñiguez, Andrés
AU - Serra, Antonio
AU - Jiménez-Quevedo, Pilar
AU - Mainar, Vicente
AU - Campo, Gianluca
AU - Tespili, Maurizio
AU - Heijer, Peter Den
AU - Bethencourt, Armando
AU - Vazquez, Nicolás
AU - Valgimigli, Marco
AU - Serruys, Patrick W.
AU - Sabaté, Manel
AU - Räber, Lorenz
AU - Vahanian, Alec
N1 - Publisher Copyright:
© Europa Digital and Publishing 2018. All rights reserved.
PY - 2018/3
Y1 - 2018/3
N2 - Aims: The aim of this substudy was to determine the five-year correlates of non-TV-related adverse events (AE) in STEMI patients included in the EXAMINATION trial. Methods and results: The EXAMINATION trial randomised 1,498 STEMI patients to bare metal or everolimus-eluting stent implantation. In this substudy, patients were analysed according to non-TV-related AE, defined as the composite of either non-TV revascularisation (non-TVR) or non-TV-related myocardial infarction (MI). At five-year follow-up, 125 patients (8.3%) exhibited 136 non-TV-related AE (124 [8.3%] non-TVR, 12 [0.8%] non-TV-related MI), accounting for 47.1% of 289 non-fatal cardiac events overall. These patients had a higher incidence of diabetes mellitus (p<0.001), arterial hypertension (p=0.032), previous MI (p=0.073), multivessel disease (p<0.001), and incomplete revascularisation (p=0.049), and a lower rate of ST-segment resolution >70% (p=0.042) as compared to the rest. At Cox analysis, previous MI (HR 1.872, 95% CI: 1.004-3.489; p=0.048), incomplete revascularisation (HR 1.746, 95% CI: 1.029-2.963; p=0.039) and diabetes (HR 1.942, 95% CI: 1.292-2.919; p=0.001) were independent correlates of non-TV-related AE. Conclusions: In STEMI patients undergoing primary percutaneous coronary intervention, previous MI, incomplete revascularisation and diabetes resulted in being independent correlates of five-year non-TV-related AE.
AB - Aims: The aim of this substudy was to determine the five-year correlates of non-TV-related adverse events (AE) in STEMI patients included in the EXAMINATION trial. Methods and results: The EXAMINATION trial randomised 1,498 STEMI patients to bare metal or everolimus-eluting stent implantation. In this substudy, patients were analysed according to non-TV-related AE, defined as the composite of either non-TV revascularisation (non-TVR) or non-TV-related myocardial infarction (MI). At five-year follow-up, 125 patients (8.3%) exhibited 136 non-TV-related AE (124 [8.3%] non-TVR, 12 [0.8%] non-TV-related MI), accounting for 47.1% of 289 non-fatal cardiac events overall. These patients had a higher incidence of diabetes mellitus (p<0.001), arterial hypertension (p=0.032), previous MI (p=0.073), multivessel disease (p<0.001), and incomplete revascularisation (p=0.049), and a lower rate of ST-segment resolution >70% (p=0.042) as compared to the rest. At Cox analysis, previous MI (HR 1.872, 95% CI: 1.004-3.489; p=0.048), incomplete revascularisation (HR 1.746, 95% CI: 1.029-2.963; p=0.039) and diabetes (HR 1.942, 95% CI: 1.292-2.919; p=0.001) were independent correlates of non-TV-related AE. Conclusions: In STEMI patients undergoing primary percutaneous coronary intervention, previous MI, incomplete revascularisation and diabetes resulted in being independent correlates of five-year non-TV-related AE.
KW - Bare metal stent
KW - Drug-eluting stent
KW - Multiple vessel disease
KW - St-elevation myocardial infarction (STEMI)
UR - http://www.scopus.com/inward/record.url?scp=85045912877&partnerID=8YFLogxK
U2 - 10.4244/EIJ-D-17-00608
DO - 10.4244/EIJ-D-17-00608
M3 - Article
C2 - 29260713
AN - SCOPUS:85045912877
SN - 1774-024X
VL - 13
SP - 1939
EP - 1945
JO - EuroIntervention
JF - EuroIntervention
IS - 16
ER -
