Conversion of Gel-Forming Crystal Needles to Easily Processable More Equant Crystals Using High-Shear Ultralow Attrition Agitation: Accelerated Ostwald Ripening without Crystal Attrition

Francesco Civati; Andrea Erxleben; Seamus Kellehan; Patrick McArdle

doi:10.1021/acs.cgd.8b01650

Conversion of Gel-Forming Crystal Needles to Easily Processable More Equant Crystals Using High-Shear Ultralow Attrition Agitation: Accelerated Ostwald Ripening without Crystal Attrition

Francesco Civati
, Andrea Erxleben
, Seamus Kellehan
, Patrick McArdle

Cellular & Molecular Medicine

University of Limerick
University of Galway

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

5 Citations (Scopus)

Abstract

We demonstrate the first examples of the transformation of gel-forming crystal needles into easily processable more equant crystals by accelerated Ostwald ripening without detectable crystal attrition. Using high solution shearing to accelerate mass transfer, diflunisal and isonicotinohydrazide gels are transformed into easily filterable crystals. High-shear ultralow attrition agitation conditions are generated by spinning with rapid reversal of the spinning direction every three seconds.

Original language	English
Pages (from-to)	1502-1504
Number of pages	3
Journal	Crystal Growth and Design
Volume	19
Issue number	3
DOIs	https://doi.org/10.1021/acs.cgd.8b01650
Publication status	Published - 6 Mar 2019

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10.1021/acs.cgd.8b01650

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title = "Conversion of Gel-Forming Crystal Needles to Easily Processable More Equant Crystals Using High-Shear Ultralow Attrition Agitation: Accelerated Ostwald Ripening without Crystal Attrition",

abstract = "We demonstrate the first examples of the transformation of gel-forming crystal needles into easily processable more equant crystals by accelerated Ostwald ripening without detectable crystal attrition. Using high solution shearing to accelerate mass transfer, diflunisal and isonicotinohydrazide gels are transformed into easily filterable crystals. High-shear ultralow attrition agitation conditions are generated by spinning with rapid reversal of the spinning direction every three seconds.",

author = "Francesco Civati and Andrea Erxleben and Seamus Kellehan and Patrick McArdle",

note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

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doi = "10.1021/acs.cgd.8b01650",

language = "English",

volume = "19",

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journal = "Crystal Growth and Design",

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Conversion of Gel-Forming Crystal Needles to Easily Processable More Equant Crystals Using High-Shear Ultralow Attrition Agitation: Accelerated Ostwald Ripening without Crystal Attrition. / Civati, Francesco; Erxleben, Andrea; Kellehan, Seamus et al.
In: Crystal Growth and Design, Vol. 19, No. 3, 06.03.2019, p. 1502-1504.

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

TY - JOUR

T1 - Conversion of Gel-Forming Crystal Needles to Easily Processable More Equant Crystals Using High-Shear Ultralow Attrition Agitation

T2 - Accelerated Ostwald Ripening without Crystal Attrition

AU - Civati, Francesco

AU - Erxleben, Andrea

AU - Kellehan, Seamus

AU - McArdle, Patrick

PY - 2019/3/6

Y1 - 2019/3/6

N2 - We demonstrate the first examples of the transformation of gel-forming crystal needles into easily processable more equant crystals by accelerated Ostwald ripening without detectable crystal attrition. Using high solution shearing to accelerate mass transfer, diflunisal and isonicotinohydrazide gels are transformed into easily filterable crystals. High-shear ultralow attrition agitation conditions are generated by spinning with rapid reversal of the spinning direction every three seconds.

AB - We demonstrate the first examples of the transformation of gel-forming crystal needles into easily processable more equant crystals by accelerated Ostwald ripening without detectable crystal attrition. Using high solution shearing to accelerate mass transfer, diflunisal and isonicotinohydrazide gels are transformed into easily filterable crystals. High-shear ultralow attrition agitation conditions are generated by spinning with rapid reversal of the spinning direction every three seconds.

UR - https://www.scopus.com/pages/publications/85061527545

U2 - 10.1021/acs.cgd.8b01650

DO - 10.1021/acs.cgd.8b01650

M3 - Article

SN - 1528-7483

VL - 19

SP - 1502

EP - 1504

JO - Crystal Growth and Design

JF - Crystal Growth and Design

IS - 3

ER -

Conversion of Gel-Forming Crystal Needles to Easily Processable More Equant Crystals Using High-Shear Ultralow Attrition Agitation: Accelerated Ostwald Ripening without Crystal Attrition

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