Abstract
DNA replication is a fundamental process within the cell cycle. The exact duplication of the genetic information ensures genome stability. Extensive research has identified the principal players required for the sequential processes: origin-licensing (a controlled order of events giving a chromosome site the potential to be initiated within the S phase of the same cell cycle); initiation (by removing the license a previous licensed site is transformed into a site where the DNA helix starts to melt); and DNA replication (copying the parental DNA by leading and tagging strand DNA-synthesis). The present report compares the advantages and limitations of studying DNA replication in the model systems Xenopus laevis (X. laevis) and in Simian Virus 40 (SV40).
| Original language | English (Ireland) |
|---|---|
| Title of host publication | ADVANCES IN MOLECULAR ONCOLOGY |
| Publisher | SPRINGER-VERLAG BERLIN |
| Number of pages | 13 |
| Volume | 604 |
| ISBN (Electronic) | 0065-2598 |
| ISBN (Print) | 0065-2598 |
| Publication status | Published - 1 Jan 2007 |
Authors (Note for portal: view the doc link for the full list of authors)
- Authors
- Oehlmann, M;Mahon, C;Nasheuer, HP