Coeliac disease: The abolition of gliadin toxicity by enzymes from Aspergillus niger

J. J. Phelan; F. M. Stevens; B. McNicholl; P. F. Fottrell; C. F. McCarthy

doi:10.1042/cs0530035

Coeliac disease: The abolition of gliadin toxicity by enzymes from Aspergillus niger

J. J. Phelan, F. M. Stevens, B. McNicholl, P. F. Fottrell, C. F. McCarthy

Medicine

University of Galway

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

12 Citations (Scopus)

Abstract

Gliadin from which carbohydrate was removed by treatment with carbohydrase from Aspergillus niger was fed to three coeliac patients in remission. Xylose absorption, mucosal morphology and brush-border enzymes were used to assess the toxicity of the carbohydrase-treated gliadin. Gliadin treated with carbohydrases did not damage the intestinal mucosa of the coeliac patients. The primary structure of the gliadin proteins was not altered by the enzyme treatment.

Original language	English
Pages (from-to)	35-43
Number of pages	9
Journal	Unknown Journal
Volume	53
Issue number	1
DOIs	https://doi.org/10.1042/cs0530035
Publication status	Published - 1977

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10.1042/cs0530035

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abstract = "Gliadin from which carbohydrate was removed by treatment with carbohydrase from Aspergillus niger was fed to three coeliac patients in remission. Xylose absorption, mucosal morphology and brush-border enzymes were used to assess the toxicity of the carbohydrase-treated gliadin. Gliadin treated with carbohydrases did not damage the intestinal mucosa of the coeliac patients. The primary structure of the gliadin proteins was not altered by the enzyme treatment.",

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Coeliac disease: The abolition of gliadin toxicity by enzymes from Aspergillus niger

Abstract

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