Cobalt-Chromium everolimus-eluting stents

Cobalt-chromium (CoCr) stents were largely born out of the need for a new generation of coronary stents preserving or improving the safety, efficacy, and deliverability of earlier iterations. This chapter provides an overview of several material and chemical properties of CoCr alloys that contribute to these stents’ superior biomechanics and biocompatibility. It discusses the technical description of the CoCr- everolimus-eluting stents (EES) and the clinical trials evaluating their safety and efficacy. The three overarching elements in the design of traditional drug-eluting stents (DES) are platform, polymer, and drug. The CoCr-EES are conscribed by the Xience V, Prime, Xpedition, and Alpine. A multitude of trials have proven the short- and long-term safety and efficacy of the CoCr-EES compared to first generation DES, and now these stents are considered the standard comparator for newer devices and scaffolds. The performance of the CoCr-EES in in-stent restenosis lesions (ISR) was evaluated in the Xience V USA prospective multicenter registry.