Clinical relevance of circulating angiogenic factors in patients with non-Hodgkin's lymphoma or Hodgkin's lymphoma

Francis J. Giles; Julie M. Vose; Kim Anh Do; Marcella M. Johnson; Taghi Manshouri; Gregory Bociek; Philip J. Bierman; Susan M. O'Brien; Hagop M. Kantarjian; James O. Armitage; Maher Albitar

doi:10.1016/j.leukres.2003.11.002

Clinical relevance of circulating angiogenic factors in patients with non-Hodgkin's lymphoma or Hodgkin's lymphoma

Francis J. Giles
, Julie M. Vose
, Kim Anh Do
, Marcella M. Johnson
, Taghi Manshouri
, Gregory Bociek
, Philip J. Bierman
, Susan M. O'Brien
, Hagop M. Kantarjian
, James O. Armitage
, Maher Albitar

Department of Cancer Biology
University of Nebraska Medical Center

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

66 Citations (Scopus)

Abstract

Vascular endothelial growth factor (VEGF), basic-fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), and angiogenin are important angiogenic factors. In 65 patients with non-Hodgkin's lymphoma (NHL), pre-treatment VEGF, bFGF, and HGF levels were significantly elevated compared to normal individuals, while angiogenin levels were significantly subnormal. In 37 patients with Hodgkin's disease, pre-treatment levels of VEGF and HGF were significantly elevated, bFGF levels were normal, and angiogenin levels were significantly subnormal. In patients with NHL, post-therapy levels of angiogenin were independently predictive of survival. Both pre-therapy and post-therapy VEGF levels were independently predictive of survival in patients with HD.

Original language	English
Pages (from-to)	595-604
Number of pages	10
Journal	Leukemia Research
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/j.leukres.2003.11.002
Publication status	Published - Jun 2004
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Angiogenin
bFGF
HGF
Hodgkin's
Lymphoma
Prognosis
Survival
VEGF

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10.1016/j.leukres.2003.11.002

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@article{24e1d92213974931809a5fde7da88edc,

title = "Clinical relevance of circulating angiogenic factors in patients with non-Hodgkin's lymphoma or Hodgkin's lymphoma",

abstract = "Vascular endothelial growth factor (VEGF), basic-fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), and angiogenin are important angiogenic factors. In 65 patients with non-Hodgkin's lymphoma (NHL), pre-treatment VEGF, bFGF, and HGF levels were significantly elevated compared to normal individuals, while angiogenin levels were significantly subnormal. In 37 patients with Hodgkin's disease, pre-treatment levels of VEGF and HGF were significantly elevated, bFGF levels were normal, and angiogenin levels were significantly subnormal. In patients with NHL, post-therapy levels of angiogenin were independently predictive of survival. Both pre-therapy and post-therapy VEGF levels were independently predictive of survival in patients with HD.",

keywords = "Angiogenin, bFGF, HGF, Hodgkin's, Lymphoma, Prognosis, Survival, VEGF",

author = "Giles, \{Francis J.\} and Vose, \{Julie M.\} and Do, \{Kim Anh\} and Johnson, \{Marcella M.\} and Taghi Manshouri and Gregory Bociek and Bierman, \{Philip J.\} and O'Brien, \{Susan M.\} and Kantarjian, \{Hagop M.\} and Armitage, \{James O.\} and Maher Albitar",

year = "2004",

month = jun,

doi = "10.1016/j.leukres.2003.11.002",

language = "English",

volume = "28",

pages = "595--604",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd",

number = "6",

}

TY - JOUR

T1 - Clinical relevance of circulating angiogenic factors in patients with non-Hodgkin's lymphoma or Hodgkin's lymphoma

AU - Giles, Francis J.

AU - Vose, Julie M.

AU - Do, Kim Anh

AU - Johnson, Marcella M.

AU - Manshouri, Taghi

AU - Bociek, Gregory

AU - Bierman, Philip J.

AU - O'Brien, Susan M.

AU - Kantarjian, Hagop M.

AU - Armitage, James O.

AU - Albitar, Maher

PY - 2004/6

Y1 - 2004/6

N2 - Vascular endothelial growth factor (VEGF), basic-fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), and angiogenin are important angiogenic factors. In 65 patients with non-Hodgkin's lymphoma (NHL), pre-treatment VEGF, bFGF, and HGF levels were significantly elevated compared to normal individuals, while angiogenin levels were significantly subnormal. In 37 patients with Hodgkin's disease, pre-treatment levels of VEGF and HGF were significantly elevated, bFGF levels were normal, and angiogenin levels were significantly subnormal. In patients with NHL, post-therapy levels of angiogenin were independently predictive of survival. Both pre-therapy and post-therapy VEGF levels were independently predictive of survival in patients with HD.

AB - Vascular endothelial growth factor (VEGF), basic-fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), and angiogenin are important angiogenic factors. In 65 patients with non-Hodgkin's lymphoma (NHL), pre-treatment VEGF, bFGF, and HGF levels were significantly elevated compared to normal individuals, while angiogenin levels were significantly subnormal. In 37 patients with Hodgkin's disease, pre-treatment levels of VEGF and HGF were significantly elevated, bFGF levels were normal, and angiogenin levels were significantly subnormal. In patients with NHL, post-therapy levels of angiogenin were independently predictive of survival. Both pre-therapy and post-therapy VEGF levels were independently predictive of survival in patients with HD.

KW - Angiogenin

KW - bFGF

KW - HGF

KW - Hodgkin's

KW - Lymphoma

KW - Prognosis

KW - Survival

KW - VEGF

UR - https://www.scopus.com/pages/publications/11144354408

U2 - 10.1016/j.leukres.2003.11.002

DO - 10.1016/j.leukres.2003.11.002

M3 - Article

C2 - 15120936

AN - SCOPUS:11144354408

SN - 0145-2126

VL - 28

SP - 595

EP - 604

JO - Leukemia Research

JF - Leukemia Research

IS - 6

ER -

Clinical relevance of circulating angiogenic factors in patients with non-Hodgkin's lymphoma or Hodgkin's lymphoma

Abstract

UN SDGs

Keywords

Access to Document

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