Clinical Performance of Direct RT-PCR Testing of Raw Saliva for Detection of SARS-CoV-2 in Symptomatic and Asymptomatic Individuals

Rosa Castillo-Bravo; Noel Lucca; Linyi Lai; Killian Marlborough; Galina Brychkova; Maryam Shideh Sakhteh; Charlie Lonergan; Justin O’Grady; Nabil-Fareed Alikhan; Alexander J. Trotter; Andrew J. Page; Breda Smyth; Peter C. McKeown; Jelena D. M. Feenstra; Camilla Ulekleiv; Oceane Sorel; Manoj Gandhi; Charles Spillane

doi:10.1128/spectrum.02229-22

Clinical Performance of Direct RT-PCR Testing of Raw Saliva for Detection of SARS-CoV-2 in Symptomatic and Asymptomatic Individuals

Rosa Castillo-Bravo
, Noel Lucca
, Linyi Lai
, Killian Marlborough
, Galina Brychkova
, Maryam Shideh Sakhteh
, Charlie Lonergan
, Justin O’Grady
, Nabil-Fareed Alikhan
, Alexander J. Trotter
, Andrew J. Page
, Breda Smyth
, Peter C. McKeown
, Jelena D. M. Feenstra
, Camilla Ulekleiv
, Oceane Sorel
, Manoj Gandhi
, Charles Spillane

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

Abstract

The scale of the COVID-19 pandemic highlighted the need for viral diagnostic systems that are accurate and could be deployed at large population scales. Large-scale diagnostic or surveillance testing of large numbers of people requires collection of infected biological samples that is easy and rapid.

Original language	English
Journal	Microbiology Spectrum
DOIs	https://doi.org/10.1128/spectrum.02229-22
Publication status	Published - 21 Dec 2022

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1128/spectrum.02229-22

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Castillo-Bravo, R., Lucca, N., Lai, L., Marlborough, K., Brychkova, G., Sakhteh, M. S., Lonergan, C., O’Grady, J., Alikhan, N.-F., Trotter, A. J., Page, A. J., Smyth, B., McKeown, P. C., Feenstra, J. D. M., Ulekleiv, C., Sorel, O., Gandhi, M., & Spillane, C. (2022). Clinical Performance of Direct RT-PCR Testing of Raw Saliva for Detection of SARS-CoV-2 in Symptomatic and Asymptomatic Individuals. Microbiology Spectrum. https://doi.org/10.1128/spectrum.02229-22

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title = "Clinical Performance of Direct RT-PCR Testing of Raw Saliva for Detection of SARS-CoV-2 in Symptomatic and Asymptomatic Individuals",

abstract = "The scale of the COVID-19 pandemic highlighted the need for viral diagnostic systems that are accurate and could be deployed at large population scales. Large-scale diagnostic or surveillance testing of large numbers of people requires collection of infected biological samples that is easy and rapid.",

author = "Rosa Castillo-Bravo and Noel Lucca and Linyi Lai and Killian Marlborough and Galina Brychkova and Sakhteh, \{Maryam Shideh\} and Charlie Lonergan and Justin O{\textquoteright}Grady and Nabil-Fareed Alikhan and Trotter, \{Alexander J.\} and Page, \{Andrew J.\} and Breda Smyth and McKeown, \{Peter C.\} and Feenstra, \{Jelena D. M.\} and Camilla Ulekleiv and Oceane Sorel and Manoj Gandhi and Charles Spillane",

year = "2022",

month = dec,

day = "21",

doi = "10.1128/spectrum.02229-22",

language = "English",

journal = "Microbiology Spectrum",

issn = "2165-0497",

publisher = "American Society for Microbiology",

}

Castillo-Bravo, R, Lucca, N, Lai, L, Marlborough, K, Brychkova, G , Sakhteh, MS, Lonergan, C, O’Grady, J, Alikhan, N-F, Trotter, AJ, Page, AJ, Smyth, B, McKeown, PC, Feenstra, JDM, Ulekleiv, C, Sorel, O, Gandhi, M & Spillane, C 2022, 'Clinical Performance of Direct RT-PCR Testing of Raw Saliva for Detection of SARS-CoV-2 in Symptomatic and Asymptomatic Individuals', Microbiology Spectrum. https://doi.org/10.1128/spectrum.02229-22

TY - JOUR

T1 - Clinical Performance of Direct RT-PCR Testing of Raw Saliva for Detection of SARS-CoV-2 in Symptomatic and Asymptomatic Individuals

AU - Castillo-Bravo, Rosa

AU - Lucca, Noel

AU - Lai, Linyi

AU - Marlborough, Killian

AU - Brychkova, Galina

AU - Sakhteh, Maryam Shideh

AU - Lonergan, Charlie

AU - O’Grady, Justin

AU - Alikhan, Nabil-Fareed

AU - Trotter, Alexander J.

AU - Page, Andrew J.

AU - Smyth, Breda

AU - McKeown, Peter C.

AU - Feenstra, Jelena D. M.

AU - Ulekleiv, Camilla

AU - Sorel, Oceane

AU - Gandhi, Manoj

AU - Spillane, Charles

PY - 2022/12/21

Y1 - 2022/12/21

N2 - The scale of the COVID-19 pandemic highlighted the need for viral diagnostic systems that are accurate and could be deployed at large population scales. Large-scale diagnostic or surveillance testing of large numbers of people requires collection of infected biological samples that is easy and rapid.

AB - The scale of the COVID-19 pandemic highlighted the need for viral diagnostic systems that are accurate and could be deployed at large population scales. Large-scale diagnostic or surveillance testing of large numbers of people requires collection of infected biological samples that is easy and rapid.

UR - http://dx.doi.org/10.1128/spectrum.02229-22

U2 - 10.1128/spectrum.02229-22

DO - 10.1128/spectrum.02229-22

M3 - Article

SN - 2165-0497

JO - Microbiology Spectrum

JF - Microbiology Spectrum

ER -

Clinical Performance of Direct RT-PCR Testing of Raw Saliva for Detection of SARS-CoV-2 in Symptomatic and Asymptomatic Individuals

Abstract

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