Clinical course and therapy of chronic myelogenous leukemia with interferon-alpha and chemotherapy

H. M. Kantarjian, F. J. Giles, S. M. O'Brien, M. Talpaz

Research output: Contribution to a Journal (Peer & Non Peer)Articlepeer-review

63 Citations (Scopus)

Abstract

This article begins with a review of the natural history of chronic myelogenous leukemia (CML), with an emphasis on prognostic features. Current standard therapy of CML with interferon-alpha based regimens, and interferon- alpha, in the context of allogenic stem cell transplantation is then discussed. Finally, some potentially effective novel agents including homoharringtonine, decitabine, ATRA, and topotecan are described.

Original languageEnglish
Pages (from-to)31-80
Number of pages50
JournalHematology/Oncology Clinics of North America
Volume12
Issue number1
DOIs
Publication statusPublished - 1998
Externally publishedYes

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