TY - JOUR
T1 - Clinical and angiographic factors associated with asymptomatic restenosis after percutaneous coronary intervention
AU - Ruygrok, Peter N.
AU - Webster, Mark W.I.
AU - De Valk, Vincent
AU - Van Es, Gerrit Anne
AU - Ormiston, John A.
AU - Morel, Marie Angèle M.
AU - Serruys, Patrick W.
PY - 2001/11/6
Y1 - 2001/11/6
N2 - Background-Angiographic restenosis after percutaneous coronary interventional procedures is more common than recurrent angina. Clinical and angiographic factors associated with asymptomatic versus symptomatic restenosis after percutaneous coronary intervention were compared. Methods and Results-All patients with angiographic restenosis from the BENESTENT I, BENESTENT II pilot, BENESTENT II, MUSIC, WEST 1, DUET, FINESS 2, FLARE, SOPHOS, and ROSE studies were analyzed. Multivariate analysis evaluated 46 clinical and angiographic variables, comparing those with and without angina. The 10 studies recruited 2690 patinets who underwent percutaneous revasculirizationand 6-month follow-up angiography (86% og hose eligible Restornosis (≥50% diameter tenosis) occured ub 607 patients and was clinically silent in 335 (55%). Male sex (P=0.008), absence of antianginal therapy with nitrates (P=0.02) and calcium channel blockers (P=0.02) at 6 months, greater reference diameter afte the procedure (P=0.04), greater referernce diameter at follow-up (P=0.004), and lesser lesion severity (percent stenosis) at 6 months (P=0.0004) were univariate predictors of asymtomatic restenosis. By multivariate analysis, only male sex (P=0.04), greater reference diameter at follow-up (P=0.002), and lesser severity at 6 months (P=0.0001) were associated with restenosis without angina. Conclusions-Approximately half of patients with angiographic restenosis have no symptoms. The only multivariate predictors of silent restenosis at 6 months were male sex, greater reference diameter at follow-up, and lesser lesion severity on follow-up angiography.
AB - Background-Angiographic restenosis after percutaneous coronary interventional procedures is more common than recurrent angina. Clinical and angiographic factors associated with asymptomatic versus symptomatic restenosis after percutaneous coronary intervention were compared. Methods and Results-All patients with angiographic restenosis from the BENESTENT I, BENESTENT II pilot, BENESTENT II, MUSIC, WEST 1, DUET, FINESS 2, FLARE, SOPHOS, and ROSE studies were analyzed. Multivariate analysis evaluated 46 clinical and angiographic variables, comparing those with and without angina. The 10 studies recruited 2690 patinets who underwent percutaneous revasculirizationand 6-month follow-up angiography (86% og hose eligible Restornosis (≥50% diameter tenosis) occured ub 607 patients and was clinically silent in 335 (55%). Male sex (P=0.008), absence of antianginal therapy with nitrates (P=0.02) and calcium channel blockers (P=0.02) at 6 months, greater reference diameter afte the procedure (P=0.04), greater referernce diameter at follow-up (P=0.004), and lesser lesion severity (percent stenosis) at 6 months (P=0.0004) were univariate predictors of asymtomatic restenosis. By multivariate analysis, only male sex (P=0.04), greater reference diameter at follow-up (P=0.002), and lesser severity at 6 months (P=0.0001) were associated with restenosis without angina. Conclusions-Approximately half of patients with angiographic restenosis have no symptoms. The only multivariate predictors of silent restenosis at 6 months were male sex, greater reference diameter at follow-up, and lesser lesion severity on follow-up angiography.
KW - Angioplasty
KW - Restenosis
KW - Stents
UR - https://www.scopus.com/pages/publications/0035818614
U2 - 10.1161/hc4401.098294
DO - 10.1161/hc4401.098294
M3 - Article
C2 - 11696467
AN - SCOPUS:0035818614
SN - 0009-7322
VL - 104
SP - 2289
EP - 2294
JO - Circulation
JF - Circulation
IS - 19
ER -