Circulating blasts following chemotherapy in pediatric patients: Implications for complete remission definition in acute leukemia

Mihaela Onciu; Elihu Estey; Francis J. Giles

doi:10.1080/10245330310001604737

Circulating blasts following chemotherapy in pediatric patients: Implications for complete remission definition in acute leukemia

Mihaela Onciu
, Elihu Estey
, Francis J. Giles

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

1 Citation (Scopus)

Abstract

We assessed the incidence of circulating blasts occurring post-chemotherapy in 1000 consecutive pediatric blood samples. Blasts with myeloid morphology (<1-3%) were present in post-chemotherapy samples in 19 of 294 (6.4%) patients with acute leukemia in remission and in 11 of 361 (3.4%) patients with solid tumors, non-Hodgkin or Hodgkin lymphoma, and were associated with ANC > 1.5 × 10⁹/l in 13 of 30 (43%) samples, and platelets > 100 × 10⁹/l in 25 of 30 (83%) samples. Our findings suggest that the absence of circulating blasts may not be a prerequisite for remission in acute myeloid leukemia (AML).

Original language	English
Pages (from-to)	295-301
Number of pages	7
Journal	Hematology
Volume	8
Issue number	5
DOIs	https://doi.org/10.1080/10245330310001604737
Publication status	Published - Oct 2003
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute leukemia
Blasts
Chemotherapy
Peripheral blood
Remission

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10.1080/10245330310001604737

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title = "Circulating blasts following chemotherapy in pediatric patients: Implications for complete remission definition in acute leukemia",

abstract = "We assessed the incidence of circulating blasts occurring post-chemotherapy in 1000 consecutive pediatric blood samples. Blasts with myeloid morphology (<1-3\%) were present in post-chemotherapy samples in 19 of 294 (6.4\%) patients with acute leukemia in remission and in 11 of 361 (3.4\%) patients with solid tumors, non-Hodgkin or Hodgkin lymphoma, and were associated with ANC > 1.5 × 109/l in 13 of 30 (43\%) samples, and platelets > 100 × 109/l in 25 of 30 (83\%) samples. Our findings suggest that the absence of circulating blasts may not be a prerequisite for remission in acute myeloid leukemia (AML).",

keywords = "Acute leukemia, Blasts, Chemotherapy, Peripheral blood, Remission",

author = "Mihaela Onciu and Elihu Estey and Giles, \{Francis J.\}",

year = "2003",

month = oct,

doi = "10.1080/10245330310001604737",

language = "English",

volume = "8",

pages = "295--301",

journal = "Hematology",

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TY - JOUR

T1 - Circulating blasts following chemotherapy in pediatric patients

T2 - Implications for complete remission definition in acute leukemia

AU - Onciu, Mihaela

AU - Estey, Elihu

AU - Giles, Francis J.

PY - 2003/10

Y1 - 2003/10

N2 - We assessed the incidence of circulating blasts occurring post-chemotherapy in 1000 consecutive pediatric blood samples. Blasts with myeloid morphology (<1-3%) were present in post-chemotherapy samples in 19 of 294 (6.4%) patients with acute leukemia in remission and in 11 of 361 (3.4%) patients with solid tumors, non-Hodgkin or Hodgkin lymphoma, and were associated with ANC > 1.5 × 109/l in 13 of 30 (43%) samples, and platelets > 100 × 109/l in 25 of 30 (83%) samples. Our findings suggest that the absence of circulating blasts may not be a prerequisite for remission in acute myeloid leukemia (AML).

AB - We assessed the incidence of circulating blasts occurring post-chemotherapy in 1000 consecutive pediatric blood samples. Blasts with myeloid morphology (<1-3%) were present in post-chemotherapy samples in 19 of 294 (6.4%) patients with acute leukemia in remission and in 11 of 361 (3.4%) patients with solid tumors, non-Hodgkin or Hodgkin lymphoma, and were associated with ANC > 1.5 × 109/l in 13 of 30 (43%) samples, and platelets > 100 × 109/l in 25 of 30 (83%) samples. Our findings suggest that the absence of circulating blasts may not be a prerequisite for remission in acute myeloid leukemia (AML).

KW - Acute leukemia

KW - Blasts

KW - Chemotherapy

KW - Peripheral blood

KW - Remission

UR - https://www.scopus.com/pages/publications/0142180058

U2 - 10.1080/10245330310001604737

DO - 10.1080/10245330310001604737

M3 - Article

AN - SCOPUS:0142180058

SN - 1024-5332

VL - 8

SP - 295

EP - 301

JO - Hematology

JF - Hematology

IS - 5

ER -

Circulating blasts following chemotherapy in pediatric patients: Implications for complete remission definition in acute leukemia

Abstract

UN SDGs

Keywords

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