Chromatin modulation and the DNA damage response

Andrew Flaus; Noel F Lowndes

doi:10.1016/j.yexcr.2006.06.031

Chromatin modulation and the DNA damage response

Molecular Biosciences

Research output: Other contribution (Published) › Other contribution

Abstract

The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, as well as ATP-dependent chromatin remodelling, in DNA damage signalling and repair of DNA double strand breaks. (c) 2006 Elsevier Inc. All rights reserved.

Original language	English (Ireland)
Media of output	Reviews
Publisher	ELSEVIER INC
Volume	312
ISBN (Print)	0014-4827
ISBN (Electronic)	0014-4827
DOIs	https://doi.org/10.1016/j.yexcr.2006.06.031
Publication status	Published - 1 Aug 2006

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10.1016/j.yexcr.2006.06.031

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title = "Chromatin modulation and the DNA damage response",

abstract = "The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, as well as ATP-dependent chromatin remodelling, in DNA damage signalling and repair of DNA double strand breaks. (c) 2006 Elsevier Inc. All rights reserved.",

author = "Andrew Flaus and Lowndes, \{Noel F\}",

year = "2006",

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AU - Lowndes, Noel F

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N2 - The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, as well as ATP-dependent chromatin remodelling, in DNA damage signalling and repair of DNA double strand breaks. (c) 2006 Elsevier Inc. All rights reserved.

AB - The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, as well as ATP-dependent chromatin remodelling, in DNA damage signalling and repair of DNA double strand breaks. (c) 2006 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.yexcr.2006.06.031

DO - 10.1016/j.yexcr.2006.06.031

M3 - Other contribution

SN - 0014-4827

VL - 312

PB - ELSEVIER INC

ER -

Chromatin modulation and the DNA damage response

Abstract

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