Chromatin modulation and the DNA damage response

Thomas Costelloe; Jennifer FitzGerald; Niall J. Murphy; Andrew Flaus; Noel F. Lowndes

doi:10.1016/j.yexcr.2006.06.031

Chromatin modulation and the DNA damage response

Thomas Costelloe
, Jennifer FitzGerald
, Niall J. Murphy
, Andrew Flaus
, Noel F. Lowndes

Molecular Biosciences

University of Galway

Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review

34 Citations (Scopus)

Abstract

The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, as well as ATP-dependent chromatin remodelling, in DNA damage signalling and repair of DNA double strand breaks.

Original language	English
Pages (from-to)	2677-2686
Number of pages	10
Journal	Experimental Cell Research
Volume	312
Issue number	14
DOIs	https://doi.org/10.1016/j.yexcr.2006.06.031
Publication status	Published - 15 Aug 2006

Keywords

Chromatin
DNA
DNA damage response
Histone

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Costelloe T, Fitzgerald J, Murphy NJ, Flaus A, Lowndes NF

Access to Document

10.1016/j.yexcr.2006.06.031

Cite this

@article{45bb7c1184a845c8828d6da7c4393505,

title = "Chromatin modulation and the DNA damage response",

abstract = "The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, as well as ATP-dependent chromatin remodelling, in DNA damage signalling and repair of DNA double strand breaks.",

keywords = "Chromatin, DNA, DNA damage response, Histone",

author = "Thomas Costelloe and Jennifer FitzGerald and Murphy, \{Niall J.\} and Andrew Flaus and Lowndes, \{Noel F.\}",

year = "2006",

month = aug,

day = "15",

doi = "10.1016/j.yexcr.2006.06.031",

language = "English",

volume = "312",

pages = "2677--2686",

journal = "Experimental Cell Research",

issn = "0014-4827",

publisher = "Elsevier Inc.",

number = "14",

}

TY - JOUR

T1 - Chromatin modulation and the DNA damage response

AU - Costelloe, Thomas

AU - FitzGerald, Jennifer

AU - Murphy, Niall J.

AU - Flaus, Andrew

AU - Lowndes, Noel F.

PY - 2006/8/15

Y1 - 2006/8/15

N2 - The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, as well as ATP-dependent chromatin remodelling, in DNA damage signalling and repair of DNA double strand breaks.

AB - The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, as well as ATP-dependent chromatin remodelling, in DNA damage signalling and repair of DNA double strand breaks.

KW - Chromatin

KW - DNA

KW - DNA damage response

KW - Histone

UR - https://www.scopus.com/pages/publications/33746747016

U2 - 10.1016/j.yexcr.2006.06.031

DO - 10.1016/j.yexcr.2006.06.031

M3 - Review article

SN - 0014-4827

VL - 312

SP - 2677

EP - 2686

JO - Experimental Cell Research

JF - Experimental Cell Research

IS - 14

ER -

Chromatin modulation and the DNA damage response

Abstract

Keywords

Authors (Note for portal: view the doc link for the full list of authors)

Access to Document

Other files and links

Fingerprint

Cite this