Cholestrol in muscle membranes

Denis R. Headon; Edward J. Barrett; Norma M. Joyce; John O'Flaherty

doi:10.1007/BF01730831

Cholestrol in muscle membranes

Denis R. Headon
, Edward J. Barrett
, Norma M. Joyce
, John O'Flaherty

University College Cork

Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review

16 Citations (Scopus)

Abstract

The composition of skeletal muscle microsomes is reviewed. Evidence for the involvement of cholesterol in the transport of calcium by vesicles derived from the sarcoplasmic reticulum is considered. Results obtained by non aqueous extractions of skeletal muscle microsomes, and by use of the cholesterol analogue 20, 25 diazacholesterol indicate that cholesterol is not involved in calcium transport by vesicles of sarcoplasmic reticulum origin. Use of density perturbation procedures indicating that cholesterol is present in muscle membranes other than those of the sarcoplasmic reticulum involved in calcium transport is discussed. The distribution of membranal cholesterol is muscle is compared to that in other tissues.

Original language	English
Pages (from-to)	117-123
Number of pages	7
Journal	Molecular and Cellular Biochemistry
Volume	17
Issue number	3
DOIs	https://doi.org/10.1007/BF01730831
Publication status	Published - Oct 1977
Externally published	Yes

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10.1007/BF01730831

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title = "Cholestrol in muscle membranes",

abstract = "The composition of skeletal muscle microsomes is reviewed. Evidence for the involvement of cholesterol in the transport of calcium by vesicles derived from the sarcoplasmic reticulum is considered. Results obtained by non aqueous extractions of skeletal muscle microsomes, and by use of the cholesterol analogue 20, 25 diazacholesterol indicate that cholesterol is not involved in calcium transport by vesicles of sarcoplasmic reticulum origin. Use of density perturbation procedures indicating that cholesterol is present in muscle membranes other than those of the sarcoplasmic reticulum involved in calcium transport is discussed. The distribution of membranal cholesterol is muscle is compared to that in other tissues.",

author = "Headon, \{Denis R.\} and Barrett, \{Edward J.\} and Joyce, \{Norma M.\} and John O'Flaherty",

year = "1977",

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doi = "10.1007/BF01730831",

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journal = "Molecular and Cellular Biochemistry",

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T1 - Cholestrol in muscle membranes

AU - Headon, Denis R.

AU - Barrett, Edward J.

AU - Joyce, Norma M.

AU - O'Flaherty, John

PY - 1977/10

Y1 - 1977/10

N2 - The composition of skeletal muscle microsomes is reviewed. Evidence for the involvement of cholesterol in the transport of calcium by vesicles derived from the sarcoplasmic reticulum is considered. Results obtained by non aqueous extractions of skeletal muscle microsomes, and by use of the cholesterol analogue 20, 25 diazacholesterol indicate that cholesterol is not involved in calcium transport by vesicles of sarcoplasmic reticulum origin. Use of density perturbation procedures indicating that cholesterol is present in muscle membranes other than those of the sarcoplasmic reticulum involved in calcium transport is discussed. The distribution of membranal cholesterol is muscle is compared to that in other tissues.

AB - The composition of skeletal muscle microsomes is reviewed. Evidence for the involvement of cholesterol in the transport of calcium by vesicles derived from the sarcoplasmic reticulum is considered. Results obtained by non aqueous extractions of skeletal muscle microsomes, and by use of the cholesterol analogue 20, 25 diazacholesterol indicate that cholesterol is not involved in calcium transport by vesicles of sarcoplasmic reticulum origin. Use of density perturbation procedures indicating that cholesterol is present in muscle membranes other than those of the sarcoplasmic reticulum involved in calcium transport is discussed. The distribution of membranal cholesterol is muscle is compared to that in other tissues.

UR - https://www.scopus.com/pages/publications/0017672802

U2 - 10.1007/BF01730831

DO - 10.1007/BF01730831

M3 - Review article

C2 - 144866

AN - SCOPUS:0017672802

SN - 0300-8177

VL - 17

SP - 117

EP - 123

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

IS - 3

ER -

Cholestrol in muscle membranes

Abstract

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