Characterization of the type I interferon locus and identification of novel genes

Matthew P. Hardy; Catherine M. Owczarek; Lars S. Jermiin; Mikael Ejdebäck; Paul J. Hertzog

doi:10.1016/j.ygeno.2004.03.003

Characterization of the type I interferon locus and identification of novel genes

Matthew P. Hardy, Catherine M. Owczarek, Lars S. Jermiin, Mikael Ejdebäck, Paul J. Hertzog

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

207 Citations (Scopus)

Abstract

The human type I interferon (IFN) genes are clustered on human chromosome 9p21 and the mouse genes are located in the region of conserved synteny on mouse chromosome 4. We have identified two novel mouse Ifna genes (Ifna12, Ifna13) and Ifnl2 (IFN-like 2, a homologue of Limitin/IFN-like 1). Another type I IFN gene was designated Ifne1. Mouse Ifne1 was expressed in ovaries and uterus but not in tissues of hematopoietic origin. IFN-ε1 has general structural characteristics of a type I IFN. These studies represent the first detailed annotation of the mouse type I IFN locus, and the products of these novel genes may have important functions in reproduction and host defense.

Original language	English
Pages (from-to)	331-345
Number of pages	15
Journal	Genomics
Volume	84
Issue number	2
DOIs	https://doi.org/10.1016/j.ygeno.2004.03.003
Publication status	Published - Aug 2004
Externally published	Yes

Keywords

Embryonic development
Genomic locus
Human chromosome 9
Interferon type I
Mouse chromosome 4

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ygeno.2004.03.003

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title = "Characterization of the type I interferon locus and identification of novel genes",

abstract = "The human type I interferon (IFN) genes are clustered on human chromosome 9p21 and the mouse genes are located in the region of conserved synteny on mouse chromosome 4. We have identified two novel mouse Ifna genes (Ifna12, Ifna13) and Ifnl2 (IFN-like 2, a homologue of Limitin/IFN-like 1). Another type I IFN gene was designated Ifne1. Mouse Ifne1 was expressed in ovaries and uterus but not in tissues of hematopoietic origin. IFN-ε1 has general structural characteristics of a type I IFN. These studies represent the first detailed annotation of the mouse type I IFN locus, and the products of these novel genes may have important functions in reproduction and host defense.",

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year = "2004",

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doi = "10.1016/j.ygeno.2004.03.003",

language = "English",

volume = "84",

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T1 - Characterization of the type I interferon locus and identification of novel genes

AU - Hardy, Matthew P.

AU - Owczarek, Catherine M.

AU - Jermiin, Lars S.

AU - Ejdebäck, Mikael

AU - Hertzog, Paul J.

PY - 2004/8

Y1 - 2004/8

N2 - The human type I interferon (IFN) genes are clustered on human chromosome 9p21 and the mouse genes are located in the region of conserved synteny on mouse chromosome 4. We have identified two novel mouse Ifna genes (Ifna12, Ifna13) and Ifnl2 (IFN-like 2, a homologue of Limitin/IFN-like 1). Another type I IFN gene was designated Ifne1. Mouse Ifne1 was expressed in ovaries and uterus but not in tissues of hematopoietic origin. IFN-ε1 has general structural characteristics of a type I IFN. These studies represent the first detailed annotation of the mouse type I IFN locus, and the products of these novel genes may have important functions in reproduction and host defense.

AB - The human type I interferon (IFN) genes are clustered on human chromosome 9p21 and the mouse genes are located in the region of conserved synteny on mouse chromosome 4. We have identified two novel mouse Ifna genes (Ifna12, Ifna13) and Ifnl2 (IFN-like 2, a homologue of Limitin/IFN-like 1). Another type I IFN gene was designated Ifne1. Mouse Ifne1 was expressed in ovaries and uterus but not in tissues of hematopoietic origin. IFN-ε1 has general structural characteristics of a type I IFN. These studies represent the first detailed annotation of the mouse type I IFN locus, and the products of these novel genes may have important functions in reproduction and host defense.

KW - Embryonic development

KW - Genomic locus

KW - Human chromosome 9

KW - Interferon type I

KW - Mouse chromosome 4

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U2 - 10.1016/j.ygeno.2004.03.003

DO - 10.1016/j.ygeno.2004.03.003

M3 - Article

SN - 0888-7543

VL - 84

SP - 331

EP - 345

JO - Genomics

JF - Genomics

IS - 2

ER -

Characterization of the type I interferon locus and identification of novel genes

Abstract

Keywords

UN SDGs

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