TY - JOUR
T1 - Characterization of a novel extended-spectrum β-lactamase phenotype from OXA-1 expression in Salmonella Typhimurium strains from Africa and Ireland.
AU - Morris, Dearbhaile
PY - 2011/8/1
Y1 - 2011/8/1
N2 - Salmonella enterica (S. Typhimurium) strains from Kenya, Malawi, and Ireland showing elevated cefepime MIC values carried bla(OXA-1). These strains were not detected by current guidelines for extended-spectrum β-lactamase production based on MIC values or clavulanate inhibition, since cefepime is a preferred substrate for OXA-1 and this enzyme is reported to be resistant to clavulanate inhibition. bla(OXA-1) was located within a class I integron and an activated P(2) promoter was identified upstream of bla(OXA-1). P(2) was activated by the insertion of a triplet 'GGG' upstream of the -10 signal. All African strains were ST313, prevalent in this continent, and the Irish isolate belonged to ST19.
AB - Salmonella enterica (S. Typhimurium) strains from Kenya, Malawi, and Ireland showing elevated cefepime MIC values carried bla(OXA-1). These strains were not detected by current guidelines for extended-spectrum β-lactamase production based on MIC values or clavulanate inhibition, since cefepime is a preferred substrate for OXA-1 and this enzyme is reported to be resistant to clavulanate inhibition. bla(OXA-1) was located within a class I integron and an activated P(2) promoter was identified upstream of bla(OXA-1). P(2) was activated by the insertion of a triplet 'GGG' upstream of the -10 signal. All African strains were ST313, prevalent in this continent, and the Irish isolate belonged to ST19.
UR - https://doi.org/10.1016/j.diagmicrobio.2011.04.007
U2 - 10.1016/j.diagmicrobio.2011.04.007
DO - 10.1016/j.diagmicrobio.2011.04.007
M3 - Article
C2 - 21767713
JO - Diagnostic Microbiology And Infectious Disease
JF - Diagnostic Microbiology And Infectious Disease
ER -