Centrosomes, DNA damage and aneuploidy

Research output: Chapter in Book or Conference Publication/ProceedingChapterpeer-review

6 Citations (Scopus)

Abstract

Understanding how the genomic instability that accompanies tumour development arises has been an important question for more than a century. One potential cause of such instability is defective chromosome segregation during mitosis. A cause of mitotic defects may lie in the acquisition of multiple mitotic spindle poles, through an increase in the number of centrosomes. Cancer cells frequently possess multiple centrosomes. DNA damaging treatments, or mutations in key DNA repair genes, also lead to centrosome amplification. Here, we review current models for how cells may lose the normal controls on centrosome duplication and acquire more than the normal number of these organelles. We also discuss how genotoxic stresses may contribute to the dysregulation of centrosome duplication and how this process may be a contributory factor in cellular transformation.

Original languageEnglish
Title of host publicationThe Centrosome
Subtitle of host publicationCell and Molecular Mechanisms of Functions and Dysfunctions in Disease
PublisherHumana Press Inc.
Pages223-241
Number of pages19
ISBN (Electronic)9781627030359
ISBN (Print)9781627030342
DOIs
Publication statusPublished - 1 Jan 2012

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