Centromeric chromatin makes its mark

Elaine Dunleavy; Alison Pidoux; Robin Allshire

doi:10.1016/j.tibs.2005.02.007

Centromeric chromatin makes its mark

Elaine Dunleavy, Alison Pidoux, Robin Allshire

University of Edinburgh

Research output: Contribution to a Journal (Peer & Non Peer) › Short survey › peer-review

19 Citations (Scopus)

Abstract

Post-translational modifications of core histones, particularly in the N terminus, seem to define different chromatin states in the genome. For instance, actively transcribed regions of euchromatin have a completely different set of 'marks' compared with silent heterochromatin. Recent analyses surprisingly demonstrate that, in addition to containing the histone H3 variant CENP-A, the centromeric chromatin that underlies the kinetochore bears a distinct combination of histone H3 modifications.

Original language	English
Pages (from-to)	172-175
Number of pages	4
Journal	Trends in Biochemical Sciences
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/j.tibs.2005.02.007
Publication status	Published - Apr 2005
Externally published	Yes

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10.1016/j.tibs.2005.02.007

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title = "Centromeric chromatin makes its mark",

abstract = "Post-translational modifications of core histones, particularly in the N terminus, seem to define different chromatin states in the genome. For instance, actively transcribed regions of euchromatin have a completely different set of 'marks' compared with silent heterochromatin. Recent analyses surprisingly demonstrate that, in addition to containing the histone H3 variant CENP-A, the centromeric chromatin that underlies the kinetochore bears a distinct combination of histone H3 modifications.",

author = "Elaine Dunleavy and Alison Pidoux and Robin Allshire",

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AU - Dunleavy, Elaine

AU - Pidoux, Alison

AU - Allshire, Robin

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N2 - Post-translational modifications of core histones, particularly in the N terminus, seem to define different chromatin states in the genome. For instance, actively transcribed regions of euchromatin have a completely different set of 'marks' compared with silent heterochromatin. Recent analyses surprisingly demonstrate that, in addition to containing the histone H3 variant CENP-A, the centromeric chromatin that underlies the kinetochore bears a distinct combination of histone H3 modifications.

AB - Post-translational modifications of core histones, particularly in the N terminus, seem to define different chromatin states in the genome. For instance, actively transcribed regions of euchromatin have a completely different set of 'marks' compared with silent heterochromatin. Recent analyses surprisingly demonstrate that, in addition to containing the histone H3 variant CENP-A, the centromeric chromatin that underlies the kinetochore bears a distinct combination of histone H3 modifications.

UR - https://www.scopus.com/pages/publications/16244368035

U2 - 10.1016/j.tibs.2005.02.007

DO - 10.1016/j.tibs.2005.02.007

M3 - Short survey

C2 - 15817392

AN - SCOPUS:16244368035

SN - 0968-0004

VL - 30

SP - 172

EP - 175

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 4

ER -

Centromeric chromatin makes its mark

Abstract

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