Abstract
Cellular longevity refers to the lifespan of an individual cell. Normal cells have a finite lifespan and typically die by undergoing apoptosis, or enter into a state of irreversible growth arrest, termed replicative senescence, at the end of that lifespan. The lifespan of a cell is a balance between pro-survival/anti-apoptotic and pro-apoptotic death-promoting factors. The role of heat shock proteins, Bcl-2 family members, antioxidant molecules, and telomere length and telomerase activity in the regulation of apoptosis and replicative senescence, will be discussed.
| Original language | English (Ireland) |
|---|---|
| Pages (from-to) | 195-206 |
| Number of pages | 12 |
| Journal | Biogerontology |
| Volume | 3 |
| Issue number | 4 |
| Publication status | Published - 1 Jan 2002 |
Keywords
- Antioxidants
- Apoptosis
- Heat shock proteins
- Oxidative stress
- Telomeres and telomerase
Authors (Note for portal: view the doc link for the full list of authors)
- Authors
- Bree RT Stenson C Grealy M Byrnes L Gorman AM Samali A
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