Abstract
The development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis-related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation; deregulation of their activation or expression can lead to the development of conditions such as neurodegenerative and autoinflammatory disorders. This review details the different caspase-associated disorders while focusing on caspase-1 inhibition as a potential therapeutic strategy. Problems facing the development of effective and safe caspase therapeutics will also be addressed.
| Original language | English |
|---|---|
| Pages (from-to) | 1502-1516 |
| Number of pages | 15 |
| Journal | Journal of Cellular and Molecular Medicine |
| Volume | 12 |
| Issue number | 5A |
| DOIs | |
| Publication status | Published - Sep 2008 |
| Externally published | Yes |
Keywords
- Apoptosis
- Inflammation
- Inhibitors
- Transplant
