Carbon nanotubes and mesenchymal stem cells: Biocompatibility, proliferation and differentiation

Emma Mooney; Peter Dockery; Udo Greiser; Mary Murphy; Valerie Barron

doi:10.1021/nl073300o

Carbon nanotubes and mesenchymal stem cells: Biocompatibility, proliferation and differentiation

Emma Mooney
, Peter Dockery
, Udo Greiser
, Mary Murphy
, Valerie Barron

University of Galway

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

208 Citations (Scopus)

Abstract

The synergy of the unique properties of carbon nanotubes (CNT) with the remarkable potential of human mesenchymal stem cells (hMSC) provides an exciting opportunity for novel therapeutic modalities. However, little is known about the impact of CNT on hMSC behavior. We report the effect of CNT on hMSC renewal, metabolic activity, and differentiation. Furthermore, we tracked the intracellular movement of CNT through the cytoplasm to a nuclear location and assessed effects on cellular ultra structure.

Original language	English
Pages (from-to)	2137-2143
Number of pages	7
Journal	Nano Letters
Volume	8
Issue number	8
DOIs	https://doi.org/10.1021/nl073300o
Publication status	Published - 1 Aug 2008

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Mooney E, Dockery P, Greiser U, Murphy M, Barron V
Mooney, E,Dockery, P,Greiser, U,Murphy, M,Barron, V

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10.1021/nl073300o

Cite this

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abstract = "The synergy of the unique properties of carbon nanotubes (CNT) with the remarkable potential of human mesenchymal stem cells (hMSC) provides an exciting opportunity for novel therapeutic modalities. However, little is known about the impact of CNT on hMSC behavior. We report the effect of CNT on hMSC renewal, metabolic activity, and differentiation. Furthermore, we tracked the intracellular movement of CNT through the cytoplasm to a nuclear location and assessed effects on cellular ultra structure.",

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AU - Murphy, Mary

AU - Barron, Valerie

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AB - The synergy of the unique properties of carbon nanotubes (CNT) with the remarkable potential of human mesenchymal stem cells (hMSC) provides an exciting opportunity for novel therapeutic modalities. However, little is known about the impact of CNT on hMSC behavior. We report the effect of CNT on hMSC renewal, metabolic activity, and differentiation. Furthermore, we tracked the intracellular movement of CNT through the cytoplasm to a nuclear location and assessed effects on cellular ultra structure.

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Carbon nanotubes and mesenchymal stem cells: Biocompatibility, proliferation and differentiation

Abstract

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