TY - JOUR
T1 - Campylobacter jejuni from patients with Guillain-Barré syndrome preferentially expresses a GD1a-like epitope
AU - Nachamkin, Irving
AU - Liu, Jirong
AU - Li, Ming
AU - Ung, Huong
AU - Moran, Anthony P.
AU - Prendergast, Martina M.
AU - Sheikh, Kazim
PY - 2002/9
Y1 - 2002/9
N2 - GM1- and GD1a-like ganglioside mimicry in Campylobacter jejuni lipooligosaccharide (LOS) is considered to be involved in the pathogenesis of Campylobacter-induced Guillain-Barré syndrome (GBS). Compared with gastroenteritis-related isolates, GBS-related C. jejuni isolates were strongly associated with the expression of GD1a-like mimicry. The presence of a few genes involved in LOS ganglioside mimicry, cst-II, cgtA, and cgtB, was also associated with GBS-related strains. GD1a-like epitope expression may be an important virulence phenotype associated with the risk of developing GBS following campylobacter infection.
AB - GM1- and GD1a-like ganglioside mimicry in Campylobacter jejuni lipooligosaccharide (LOS) is considered to be involved in the pathogenesis of Campylobacter-induced Guillain-Barré syndrome (GBS). Compared with gastroenteritis-related isolates, GBS-related C. jejuni isolates were strongly associated with the expression of GD1a-like mimicry. The presence of a few genes involved in LOS ganglioside mimicry, cst-II, cgtA, and cgtB, was also associated with GBS-related strains. GD1a-like epitope expression may be an important virulence phenotype associated with the risk of developing GBS following campylobacter infection.
UR - https://www.scopus.com/pages/publications/0036718373
U2 - 10.1128/IAI.70.9.5299-5303.2002
DO - 10.1128/IAI.70.9.5299-5303.2002
M3 - Article
SN - 0019-9567
VL - 70
SP - 5299
EP - 5303
JO - Infection and Immunity
JF - Infection and Immunity
IS - 9
ER -