CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia

Alastair G. Cardno; Timothy Bowen; Carol A. Guy; Lisa A. Jones; Geraldine McCarthy; Nigel M. Williams; Kieran C. Murphy; Gillian Spurlock; Marion Gray; Robert D. Sanders; Nick Craddock; Peter McGuffin; Michael J. Owen; Michael C. O'Donovan

doi:10.1016/S0006-3223(99)00033-5

CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia

Alastair G. Cardno, Timothy Bowen, Carol A. Guy, Lisa A. Jones, Geraldine McCarthy, Nigel M. Williams, Kieran C. Murphy, Gillian Spurlock, Marion Gray, Robert D. Sanders, Nick Craddock, Peter McGuffin, Michael J. Owen, Michael C. O'Donovan

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

40 Citations (Scopus)

Abstract

Background: Long CAG repeats in the hKCa3 potassium channel gene have been associated with schizophrenia. We sought evidence for associations between this polymorphism and aspects of the schizophrenia phenotype. Methods: Associations were investigated between CAG repeat length and gender, age of illness onset, and psychotic symptom dimensions in 203 unrelated individuals with DSM-IIIR schizophrenia. Results: No association was found between CAG repeat length and gender or age of onset. Long CAG repeats were associated with higher negative symptom dimension scores. Conclusions: This study provides preliminary evidence that genetic liability to negative symptoms in schizophrenia may be partly mediated through the hKCa3 gene.

Original language	English
Pages (from-to)	1592-1596
Number of pages	5
Journal	Biological Psychiatry
Volume	45
Issue number	12
DOIs	https://doi.org/10.1016/S0006-3223(99)00033-5
Publication status	Published - 15 Jun 1999
Externally published	Yes

Keywords

Association
Negative symptoms
Potassium channel
Schizophrenia
Trinucleotide repeats

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10.1016/S0006-3223(99)00033-5

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Cardno, A. G., Bowen, T., Guy, C. A., Jones, L. A., McCarthy, G., Williams, N. M., Murphy, K. C., Spurlock, G., Gray, M., Sanders, R. D., Craddock, N., McGuffin, P., Owen, M. J., & O'Donovan, M. C. (1999). CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia. Biological Psychiatry, 45(12), 1592-1596. https://doi.org/10.1016/S0006-3223(99)00033-5

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title = "CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia",

abstract = "Background: Long CAG repeats in the hKCa3 potassium channel gene have been associated with schizophrenia. We sought evidence for associations between this polymorphism and aspects of the schizophrenia phenotype. Methods: Associations were investigated between CAG repeat length and gender, age of illness onset, and psychotic symptom dimensions in 203 unrelated individuals with DSM-IIIR schizophrenia. Results: No association was found between CAG repeat length and gender or age of onset. Long CAG repeats were associated with higher negative symptom dimension scores. Conclusions: This study provides preliminary evidence that genetic liability to negative symptoms in schizophrenia may be partly mediated through the hKCa3 gene.",

keywords = "Association, Negative symptoms, Potassium channel, Schizophrenia, Trinucleotide repeats",

author = "Cardno, {Alastair G.} and Timothy Bowen and Guy, {Carol A.} and Jones, {Lisa A.} and Geraldine McCarthy and Williams, {Nigel M.} and Murphy, {Kieran C.} and Gillian Spurlock and Marion Gray and Sanders, {Robert D.} and Nick Craddock and Peter McGuffin and Owen, {Michael J.} and O'Donovan, {Michael C.}",

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doi = "10.1016/S0006-3223(99)00033-5",

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AU - Cardno, Alastair G.

AU - Bowen, Timothy

AU - Guy, Carol A.

AU - Jones, Lisa A.

AU - McCarthy, Geraldine

AU - Williams, Nigel M.

AU - Murphy, Kieran C.

AU - Spurlock, Gillian

AU - Gray, Marion

AU - Sanders, Robert D.

AU - Craddock, Nick

AU - McGuffin, Peter

AU - Owen, Michael J.

AU - O'Donovan, Michael C.

PY - 1999/6/15

Y1 - 1999/6/15

N2 - Background: Long CAG repeats in the hKCa3 potassium channel gene have been associated with schizophrenia. We sought evidence for associations between this polymorphism and aspects of the schizophrenia phenotype. Methods: Associations were investigated between CAG repeat length and gender, age of illness onset, and psychotic symptom dimensions in 203 unrelated individuals with DSM-IIIR schizophrenia. Results: No association was found between CAG repeat length and gender or age of onset. Long CAG repeats were associated with higher negative symptom dimension scores. Conclusions: This study provides preliminary evidence that genetic liability to negative symptoms in schizophrenia may be partly mediated through the hKCa3 gene.

AB - Background: Long CAG repeats in the hKCa3 potassium channel gene have been associated with schizophrenia. We sought evidence for associations between this polymorphism and aspects of the schizophrenia phenotype. Methods: Associations were investigated between CAG repeat length and gender, age of illness onset, and psychotic symptom dimensions in 203 unrelated individuals with DSM-IIIR schizophrenia. Results: No association was found between CAG repeat length and gender or age of onset. Long CAG repeats were associated with higher negative symptom dimension scores. Conclusions: This study provides preliminary evidence that genetic liability to negative symptoms in schizophrenia may be partly mediated through the hKCa3 gene.

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KW - Negative symptoms

KW - Potassium channel

KW - Schizophrenia

KW - Trinucleotide repeats

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DO - 10.1016/S0006-3223(99)00033-5

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SP - 1592

EP - 1596

JO - Biological Psychiatry

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ER -

CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia

Abstract

Keywords

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