Burkitt translocation (8;22)(q24;q11) in a patient with multiple myeloma

Rogan Mon Look; Stephen Wong Lim; Rhona Rebecca Schreck; Stephen Lee; Marie Perrelli Fuerst; Grace Natividad Lawrence; Donato Absalom Kusuanco; Christine Elisabeth Kessler; Francis Joseph Giles

doi:10.1016/0165-4608(95)00049-U

Burkitt translocation (8;22)(q24;q11) in a patient with multiple myeloma

Rogan Mon Look
, Stephen Wong Lim
, Rhona Rebecca Schreck
, Stephen Lee
, Marie Perrelli Fuerst
, Grace Natividad Lawrence
, Donato Absalom Kusuanco
, Christine Elisabeth Kessler
, Francis Joseph Giles

Department of Medicine
Department of Medical Genetics
Department of Pathology, Laboratory Medicine, Cedars-Sinai Medical Center

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

3 Citations (Scopus)

Abstract

The prevalance of chromosomal abnormalities in multiple myeloma (MM) has been difficult to detect by karyotyping primarily because of the low proliferative rate of malignant plasma cells. The reported incidences of abnormal karyotypes range from 24% to 63% in bone marrows obtained from MM patients, with the higher rates being seen in aggressive disease [1-8]. Detection of abnormal karyotypes in MM has been associated with a poor prognosis. We report a MM patient with an 8;22 Burkitt translocation, the first such reported case.

Original language	English
Pages (from-to)	100-102
Number of pages	3
Journal	Cancer Genetics and Cytogenetics
Volume	82
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(95)00049-U
Publication status	Published - 15 Jul 1995
Externally published	Yes

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10.1016/0165-4608(95)00049-U

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@article{da878d29a8a84d58b7124e4ee9b47acc,

title = "Burkitt translocation (8;22)(q24;q11) in a patient with multiple myeloma",

abstract = "The prevalance of chromosomal abnormalities in multiple myeloma (MM) has been difficult to detect by karyotyping primarily because of the low proliferative rate of malignant plasma cells. The reported incidences of abnormal karyotypes range from 24\% to 63\% in bone marrows obtained from MM patients, with the higher rates being seen in aggressive disease [1-8]. Detection of abnormal karyotypes in MM has been associated with a poor prognosis. We report a MM patient with an 8;22 Burkitt translocation, the first such reported case.",

author = "Look, \{Rogan Mon\} and Lim, \{Stephen Wong\} and Schreck, \{Rhona Rebecca\} and Stephen Lee and Fuerst, \{Marie Perrelli\} and Lawrence, \{Grace Natividad\} and Kusuanco, \{Donato Absalom\} and Kessler, \{Christine Elisabeth\} and Giles, \{Francis Joseph\}",

year = "1995",

month = jul,

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doi = "10.1016/0165-4608(95)00049-U",

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T1 - Burkitt translocation (8;22)(q24;q11) in a patient with multiple myeloma

AU - Look, Rogan Mon

AU - Lim, Stephen Wong

AU - Schreck, Rhona Rebecca

AU - Lee, Stephen

AU - Fuerst, Marie Perrelli

AU - Lawrence, Grace Natividad

AU - Kusuanco, Donato Absalom

AU - Kessler, Christine Elisabeth

AU - Giles, Francis Joseph

PY - 1995/7/15

Y1 - 1995/7/15

N2 - The prevalance of chromosomal abnormalities in multiple myeloma (MM) has been difficult to detect by karyotyping primarily because of the low proliferative rate of malignant plasma cells. The reported incidences of abnormal karyotypes range from 24% to 63% in bone marrows obtained from MM patients, with the higher rates being seen in aggressive disease [1-8]. Detection of abnormal karyotypes in MM has been associated with a poor prognosis. We report a MM patient with an 8;22 Burkitt translocation, the first such reported case.

AB - The prevalance of chromosomal abnormalities in multiple myeloma (MM) has been difficult to detect by karyotyping primarily because of the low proliferative rate of malignant plasma cells. The reported incidences of abnormal karyotypes range from 24% to 63% in bone marrows obtained from MM patients, with the higher rates being seen in aggressive disease [1-8]. Detection of abnormal karyotypes in MM has been associated with a poor prognosis. We report a MM patient with an 8;22 Burkitt translocation, the first such reported case.

UR - https://www.scopus.com/pages/publications/0029149527

U2 - 10.1016/0165-4608(95)00049-U

DO - 10.1016/0165-4608(95)00049-U

M3 - Article

C2 - 7664237

AN - SCOPUS:0029149527

SN - 0165-4608

VL - 82

SP - 100

EP - 102

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 2

ER -

Burkitt translocation (8;22)(q24;q11) in a patient with multiple myeloma

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