Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives

Hugh S O'Neill; Laura B Gallagher; Janice O'Sullivan; William Whyte; Clive Curley; Eimear Dolan; Aamir Hameed; Joanne O'Dwyer; Christina Payne; Daniel O'Reilly; Eduardo Ruiz-Hernandez; Ellen T Roche; Fergal J O'Brien; Sally Ann Cryan; Helena Kelly; Bruce Murphy; Garry P Duffy

doi:10.1002/adma.201505349

Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives

Hugh S O'Neill, Laura B Gallagher, Janice O'Sullivan, William Whyte, Clive Curley, Eimear Dolan, Aamir Hameed, Joanne O'Dwyer, Christina Payne, Daniel O'Reilly, Eduardo Ruiz-Hernandez, Ellen T Roche, Fergal J O'Brien, Sally Ann Cryan, Helena Kelly, Bruce Murphy, Garry P Duffy

Research output: Contribution to a Journal (Peer & Non Peer) › Review article › peer-review

Abstract

Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical and preclinical studies delivering simple suspensions of cells, macromolecule, and small molecules to more advanced delivery methods utilizing biomaterial scaffolds as depots for localized targeted delivery to the damaged and ischemic myocardium. Here, regenerative strategies for cardiac tissue engineering with a focus on advanced delivery strategies and the use of multimodal therapeutic strategies are reviewed.

Original language	English
Pages (from-to)	5648-61
Number of pages	14
Journal	Advanced Materials
Volume	28
Issue number	27
DOIs	https://doi.org/10.1002/adma.201505349
Publication status	Published - Jul 2016
Externally published	Yes

Keywords

Biocompatible Materials
Drug Delivery Systems
Heart
Tissue Engineering
Tissue Scaffolds

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10.1002/adma.201505349

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O'Neill, H. S., Gallagher, L. B., O'Sullivan, J., Whyte, W., Curley, C., Dolan, E., Hameed, A., O'Dwyer, J., Payne, C., O'Reilly, D., Ruiz-Hernandez, E., Roche, E. T., O'Brien, F. J., Cryan, S. A., Kelly, H., Murphy, B., & Duffy, G. P. (2016). Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives. Advanced Materials, 28(27), 5648-61. https://doi.org/10.1002/adma.201505349

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title = "Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives",

abstract = "Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical and preclinical studies delivering simple suspensions of cells, macromolecule, and small molecules to more advanced delivery methods utilizing biomaterial scaffolds as depots for localized targeted delivery to the damaged and ischemic myocardium. Here, regenerative strategies for cardiac tissue engineering with a focus on advanced delivery strategies and the use of multimodal therapeutic strategies are reviewed.",

keywords = "Biocompatible Materials, Drug Delivery Systems, Heart, Tissue Engineering, Tissue Scaffolds",

author = "O'Neill, {Hugh S} and Gallagher, {Laura B} and Janice O'Sullivan and William Whyte and Clive Curley and Eimear Dolan and Aamir Hameed and Joanne O'Dwyer and Christina Payne and Daniel O'Reilly and Eduardo Ruiz-Hernandez and Roche, {Ellen T} and O'Brien, {Fergal J} and Cryan, {Sally Ann} and Helena Kelly and Bruce Murphy and Duffy, {Garry P}",

note = "{\textcopyright} 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2016",

month = jul,

doi = "10.1002/adma.201505349",

language = "English",

volume = "28",

pages = "5648--61",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-Blackwell",

number = "27",

}

O'Neill, HS, Gallagher, LB, O'Sullivan, J, Whyte, W, Curley, C, Dolan, E, Hameed, A, O'Dwyer, J, Payne, C, O'Reilly, D, Ruiz-Hernandez, E, Roche, ET, O'Brien, FJ, Cryan, SA, Kelly, H, Murphy, B & Duffy, GP 2016, 'Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives', Advanced Materials, vol. 28, no. 27, pp. 5648-61. https://doi.org/10.1002/adma.201505349

TY - JOUR

T1 - Biomaterial-Enhanced Cell and Drug Delivery

T2 - Lessons Learned in the Cardiac Field and Future Perspectives

AU - O'Neill, Hugh S

AU - Gallagher, Laura B

AU - O'Sullivan, Janice

AU - Whyte, William

AU - Curley, Clive

AU - Dolan, Eimear

AU - Hameed, Aamir

AU - O'Dwyer, Joanne

AU - Payne, Christina

AU - O'Reilly, Daniel

AU - Ruiz-Hernandez, Eduardo

AU - Roche, Ellen T

AU - O'Brien, Fergal J

AU - Cryan, Sally Ann

AU - Kelly, Helena

AU - Murphy, Bruce

AU - Duffy, Garry P

PY - 2016/7

Y1 - 2016/7

N2 - Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical and preclinical studies delivering simple suspensions of cells, macromolecule, and small molecules to more advanced delivery methods utilizing biomaterial scaffolds as depots for localized targeted delivery to the damaged and ischemic myocardium. Here, regenerative strategies for cardiac tissue engineering with a focus on advanced delivery strategies and the use of multimodal therapeutic strategies are reviewed.

AB - Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical and preclinical studies delivering simple suspensions of cells, macromolecule, and small molecules to more advanced delivery methods utilizing biomaterial scaffolds as depots for localized targeted delivery to the damaged and ischemic myocardium. Here, regenerative strategies for cardiac tissue engineering with a focus on advanced delivery strategies and the use of multimodal therapeutic strategies are reviewed.

KW - Biocompatible Materials

KW - Drug Delivery Systems

KW - Heart

KW - Tissue Engineering

KW - Tissue Scaffolds

U2 - 10.1002/adma.201505349

DO - 10.1002/adma.201505349

M3 - Review article

C2 - 26840955

SN - 0935-9648

VL - 28

SP - 5648

EP - 5661

JO - Advanced Materials

JF - Advanced Materials

IS - 27

ER -

Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives

Abstract

Keywords

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