Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold

Yunxue Zhao; Min Liu; Vincent Chagnault; Juying Wang; Xiumei Zhang; Paul V. Murphy

doi:10.1016/j.bmcl.2010.11.088

Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold

Yunxue Zhao, Min Liu, Vincent Chagnault, Juying Wang, Xiumei Zhang, Paul V. Murphy

Infectious Disease

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7 Citations (Scopus)

Abstract

Previously the synthesis of novel somatostatin mimetic from 1-deoxynojirimycin (DNJ) led to identification of a compound with affinity for human somatostatin receptor subtypes 4 and 5 (hSSTR4 and hSSTR5). Here we examined the properties of this peptidomimetic in a human umbilical vein endothelial cell (HUVEC) based assays. The peptidomimetic prevented capillary tube formation based on HUVECs. It also inhibited HUVEC proliferation by inducing G1 phase cell cycle arrest and apoptosis. Stress fiber assembly and cell migration in HUVECs was markedly suppressed by the somatostatin receptor ligand.

Original language	English
Pages (from-to)	824-828
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2010.11.088
Publication status	Published - 15 Jan 2011

Keywords

Angiogenesis
Apoptosis
Cell cycle
Migration
Peptidomimetic
Somatostatin
Stress fiber

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10.1016/j.bmcl.2010.11.088

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title = "Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold",

abstract = "Previously the synthesis of novel somatostatin mimetic from 1-deoxynojirimycin (DNJ) led to identification of a compound with affinity for human somatostatin receptor subtypes 4 and 5 (hSSTR4 and hSSTR5). Here we examined the properties of this peptidomimetic in a human umbilical vein endothelial cell (HUVEC) based assays. The peptidomimetic prevented capillary tube formation based on HUVECs. It also inhibited HUVEC proliferation by inducing G1 phase cell cycle arrest and apoptosis. Stress fiber assembly and cell migration in HUVECs was markedly suppressed by the somatostatin receptor ligand.",

keywords = "Angiogenesis, Apoptosis, Cell cycle, Migration, Peptidomimetic, Somatostatin, Stress fiber",

author = "Yunxue Zhao and Min Liu and Vincent Chagnault and Juying Wang and Xiumei Zhang and Murphy, \{Paul V.\}",

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doi = "10.1016/j.bmcl.2010.11.088",

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T1 - Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold

AU - Zhao, Yunxue

AU - Liu, Min

AU - Chagnault, Vincent

AU - Wang, Juying

AU - Zhang, Xiumei

AU - Murphy, Paul V.

PY - 2011/1/15

Y1 - 2011/1/15

N2 - Previously the synthesis of novel somatostatin mimetic from 1-deoxynojirimycin (DNJ) led to identification of a compound with affinity for human somatostatin receptor subtypes 4 and 5 (hSSTR4 and hSSTR5). Here we examined the properties of this peptidomimetic in a human umbilical vein endothelial cell (HUVEC) based assays. The peptidomimetic prevented capillary tube formation based on HUVECs. It also inhibited HUVEC proliferation by inducing G1 phase cell cycle arrest and apoptosis. Stress fiber assembly and cell migration in HUVECs was markedly suppressed by the somatostatin receptor ligand.

AB - Previously the synthesis of novel somatostatin mimetic from 1-deoxynojirimycin (DNJ) led to identification of a compound with affinity for human somatostatin receptor subtypes 4 and 5 (hSSTR4 and hSSTR5). Here we examined the properties of this peptidomimetic in a human umbilical vein endothelial cell (HUVEC) based assays. The peptidomimetic prevented capillary tube formation based on HUVECs. It also inhibited HUVEC proliferation by inducing G1 phase cell cycle arrest and apoptosis. Stress fiber assembly and cell migration in HUVECs was markedly suppressed by the somatostatin receptor ligand.

KW - Angiogenesis

KW - Apoptosis

KW - Cell cycle

KW - Migration

KW - Peptidomimetic

KW - Somatostatin

KW - Stress fiber

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DO - 10.1016/j.bmcl.2010.11.088

M3 - Article

SN - 0960-894X

VL - 21

SP - 824

EP - 828

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold

Abstract

Keywords

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