BIOCHEMICAL SOCIETY TRANSACTIONS

Noel F Lowndes

BIOCHEMICAL SOCIETY TRANSACTIONS

Molecular Biosciences

Research output: Chapter in Book or Conference Publication/Proceeding › Conference Publication › peer-review

Abstract

Eukaryotic cells have evolved surveillance mechanisms, known as DNA-damage checkpoints, that sense and respond to genome damage. DNA-damage checkpoint pathways ensure co-ordinated cellular responses to DNA damage, including cell cycle delays and activation of repair mechanisms. RAD9, from Saccharomyces cerevisiae, was the first damage checkpoint gene to be identified, although its biochemical function remained unknown until recently. This review examines briefly work that provides significant insight into how Rad9 activates the checkpoint signalling kinase Rad53.

Original language	English (Ireland)
Title of host publication	Role of the Saccharomyces in sensing and responding cerevisiae Rad9 protein to DNA damage
Number of pages	5
Volume	31
Publication status	Published - 1 Feb 2003

Authors (Note for portal: view the doc link for the full list of authors)

Authors
Toh, GWL,Lowndes, NF

Cite this

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abstract = "Eukaryotic cells have evolved surveillance mechanisms, known as DNA-damage checkpoints, that sense and respond to genome damage. DNA-damage checkpoint pathways ensure co-ordinated cellular responses to DNA damage, including cell cycle delays and activation of repair mechanisms. RAD9, from Saccharomyces cerevisiae, was the first damage checkpoint gene to be identified, although its biochemical function remained unknown until recently. This review examines briefly work that provides significant insight into how Rad9 activates the checkpoint signalling kinase Rad53.",

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N2 - Eukaryotic cells have evolved surveillance mechanisms, known as DNA-damage checkpoints, that sense and respond to genome damage. DNA-damage checkpoint pathways ensure co-ordinated cellular responses to DNA damage, including cell cycle delays and activation of repair mechanisms. RAD9, from Saccharomyces cerevisiae, was the first damage checkpoint gene to be identified, although its biochemical function remained unknown until recently. This review examines briefly work that provides significant insight into how Rad9 activates the checkpoint signalling kinase Rad53.

AB - Eukaryotic cells have evolved surveillance mechanisms, known as DNA-damage checkpoints, that sense and respond to genome damage. DNA-damage checkpoint pathways ensure co-ordinated cellular responses to DNA damage, including cell cycle delays and activation of repair mechanisms. RAD9, from Saccharomyces cerevisiae, was the first damage checkpoint gene to be identified, although its biochemical function remained unknown until recently. This review examines briefly work that provides significant insight into how Rad9 activates the checkpoint signalling kinase Rad53.

M3 - Conference Publication

VL - 31

BT - Role of the Saccharomyces in sensing and responding cerevisiae Rad9 protein to DNA damage

ER -

BIOCHEMICAL SOCIETY TRANSACTIONS

Abstract

Authors (Note for portal: view the doc link for the full list of authors)

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