Bioactive composites of hydroxyapatite/polyvinylpyrrolidone for bone regeneration applications

Youssef Guesmi; Hassen Agougui; Mahjoub Jabli; Amir M. Alsharabasy

doi:10.1080/00986445.2018.1486302

Bioactive composites of hydroxyapatite/polyvinylpyrrolidone for bone regeneration applications

Youssef Guesmi
, Hassen Agougui
, Mahjoub Jabli
, Amir M. Alsharabasy

Faculté des Sciences de Monastir
Textile Materials and Process Research Unit
National Center for Radiation Research and Technology

Research output: Contribution to a Journal (Peer & Non Peer) › Article › peer-review

14 Citations (Scopus)

Abstract

The implantation of bioactive composites for bone repair applications has recently gained the attention of many research groups. The present paper introduces a method for grafting of polyvinylpyrrolidone on the surface of hydroxyapatite (CaHAp) microcrystals by wet precipitation method to manufacture new composite scaffolds with suitability for bone tissue engineering. After grafting with the polymer, the degree of CaHAp crystallinity decreased, and its thermal behavior changed indicating a strong interaction between them. Homogenous clusters of CaHAp particles within the polymeric matrix were observed in combination with an increase in the roughness of the resulting structures. Bioactivity of the composites was tested using MTT assay; a higher viability of the seeded cells was observed relative to those cultured with CaHAp powder.

Original language	English
Pages (from-to)	279-288
Number of pages	10
Journal	Chemical Engineering Communications
Volume	206
Issue number	3
DOIs	https://doi.org/10.1080/00986445.2018.1486302
Publication status	Published - 4 Mar 2019
Externally published	Yes

Keywords

Bone regeneration
Composite implants
Micro-hydroxyapatite
Polyvinylpyrrolidone
Surface grafting
Wet precipitation

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10.1080/00986445.2018.1486302

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title = "Bioactive composites of hydroxyapatite/polyvinylpyrrolidone for bone regeneration applications",

abstract = "The implantation of bioactive composites for bone repair applications has recently gained the attention of many research groups. The present paper introduces a method for grafting of polyvinylpyrrolidone on the surface of hydroxyapatite (CaHAp) microcrystals by wet precipitation method to manufacture new composite scaffolds with suitability for bone tissue engineering. After grafting with the polymer, the degree of CaHAp crystallinity decreased, and its thermal behavior changed indicating a strong interaction between them. Homogenous clusters of CaHAp particles within the polymeric matrix were observed in combination with an increase in the roughness of the resulting structures. Bioactivity of the composites was tested using MTT assay; a higher viability of the seeded cells was observed relative to those cultured with CaHAp powder.",

keywords = "Bone regeneration, Composite implants, Micro-hydroxyapatite, Polyvinylpyrrolidone, Surface grafting, Wet precipitation",

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doi = "10.1080/00986445.2018.1486302",

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T1 - Bioactive composites of hydroxyapatite/polyvinylpyrrolidone for bone regeneration applications

AU - Guesmi, Youssef

AU - Agougui, Hassen

AU - Jabli, Mahjoub

AU - Alsharabasy, Amir M.

PY - 2019/3/4

Y1 - 2019/3/4

N2 - The implantation of bioactive composites for bone repair applications has recently gained the attention of many research groups. The present paper introduces a method for grafting of polyvinylpyrrolidone on the surface of hydroxyapatite (CaHAp) microcrystals by wet precipitation method to manufacture new composite scaffolds with suitability for bone tissue engineering. After grafting with the polymer, the degree of CaHAp crystallinity decreased, and its thermal behavior changed indicating a strong interaction between them. Homogenous clusters of CaHAp particles within the polymeric matrix were observed in combination with an increase in the roughness of the resulting structures. Bioactivity of the composites was tested using MTT assay; a higher viability of the seeded cells was observed relative to those cultured with CaHAp powder.

AB - The implantation of bioactive composites for bone repair applications has recently gained the attention of many research groups. The present paper introduces a method for grafting of polyvinylpyrrolidone on the surface of hydroxyapatite (CaHAp) microcrystals by wet precipitation method to manufacture new composite scaffolds with suitability for bone tissue engineering. After grafting with the polymer, the degree of CaHAp crystallinity decreased, and its thermal behavior changed indicating a strong interaction between them. Homogenous clusters of CaHAp particles within the polymeric matrix were observed in combination with an increase in the roughness of the resulting structures. Bioactivity of the composites was tested using MTT assay; a higher viability of the seeded cells was observed relative to those cultured with CaHAp powder.

KW - Bone regeneration

KW - Composite implants

KW - Micro-hydroxyapatite

KW - Polyvinylpyrrolidone

KW - Surface grafting

KW - Wet precipitation

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DO - 10.1080/00986445.2018.1486302

M3 - Article

SN - 0098-6445

VL - 206

SP - 279

EP - 288

JO - Chemical Engineering Communications

JF - Chemical Engineering Communications

IS - 3

ER -

Bioactive composites of hydroxyapatite/polyvinylpyrrolidone for bone regeneration applications

Abstract

Keywords

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