Augmentation index and multivariate risk analysis for assessment of peripheral vascular disease

Peripheral vascular disease (PVD) is responsible for a significant morbidity and mortality worldwide. Ankle brachial pressure index (ABPI) is the non-invasive investigation of choice for PVD. We have previously demonstrated that radial augmentation index (rAI) may have a role in the assessment of PVD essentially negatively correlating with ABPI in an initial study we carried out. We sought to follow this with a larger study examining multiple risk factors in an age and gender matched group. 63 subjects (30 known PVD and 33 controls) had ABPI measured and 18 risk factors and biochemical measurements measured. They then underwent pulse wave analysis and average rAI recorded. The framingham risk Score for symptomatic PVD was also calculated. There was a significant negative correlation between ABPI and rAI (r = -0.32, p\0.005) in the group overallTo conclude our PVD and control groups were well matched in terms of age, gender and many risk factors but those in the PVD group had a much greater smoking history. A lower ABPI correlated well with the presence of symptomatic PVD. There was a correlation between rAI and PVDit was not statistically significant, however, we feel further study is warranted and that radial augmentation index is a useful assessment tool in PVD. Conflict of interest: None Disclosures: None.