TY - JOUR
T1 - Audio frequency in vivo optical coherence elastography
AU - Adie, Steven G.
AU - Kennedy, Brendan F.
AU - Armstrong, Julian J.
AU - Alexandrov, Sergey A.
AU - Sampson, David D.
PY - 2009
Y1 - 2009
N2 - We present a new approach to optical coherence elastography (OCE), which probes the local elastic properties of tissue by using optical coherence tomography to measure the effect of an applied stimulus in the audio frequency range. We describe the approach, based on analysis of the Bessel frequency spectrum of the interferometric signal detected from scatterers undergoing periodic motion in response to an applied stimulus. We present quantitative results of sub-micron excitation at 820 Hz in a layered phantom and the first such measurements in human skin in vivo.
AB - We present a new approach to optical coherence elastography (OCE), which probes the local elastic properties of tissue by using optical coherence tomography to measure the effect of an applied stimulus in the audio frequency range. We describe the approach, based on analysis of the Bessel frequency spectrum of the interferometric signal detected from scatterers undergoing periodic motion in response to an applied stimulus. We present quantitative results of sub-micron excitation at 820 Hz in a layered phantom and the first such measurements in human skin in vivo.
UR - https://www.scopus.com/pages/publications/67650742064
U2 - 10.1088/0031-9155/54/10/011
DO - 10.1088/0031-9155/54/10/011
M3 - Article
C2 - 19420415
AN - SCOPUS:67650742064
SN - 0031-9155
VL - 54
SP - 3129
EP - 3139
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
IS - 10
ER -